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首页> 外文期刊>Therapeutic advances in cardiovascular disease. >Remote post-conditioning and allopurinol reduce ischemia-reperfusion injury in an infra-renal ischemia model
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Remote post-conditioning and allopurinol reduce ischemia-reperfusion injury in an infra-renal ischemia model

机译：远程后处理和别嘌呤醇减少肾缺血模型中的缺血再灌注损伤

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摘要

The aim of this study was to evaluate the effects of the antioxidant allopurinol and ischemic post-conditioning on the deleterious effects of ischemia followed by reperfusion (I/R) in a standardized model of ischemia involving infra-renal aortic occlusion in rats. The animals were randomly divided into five groups: (A) animals not subjected to ischemia; (B) animals subjected to 2 h of ischemia and reperfusion only once; (C) animals given an allopurinol dose by gavage, then subjected to 2 h of ischemia and reperfusion only once; (D) animals subjected to 2 h of ischemia and post-conditioning and (E) animals that received allopurinol, then subjected to 2 h of ischemia and post-conditioning. The blood samples and small intestine segments were harvested for analysis after 3 days. The protective effects of the use of allopurinol and ischemic post-conditioning were observed by measuring aspartate aminotransferase, alanine aminotransferase and lactate levels. The benefits of post-conditioning were evident from the total antioxidant capacity and creatinine levels, but these could not ascertain any positive effects of allopurinol. The histological analysis of mesentery revealed that both methods were effective in minimizing the harmful effects of the ischemia and reperfusion process. Individual protocols significantly reduced I/R systemic injuries, but no additional protection was observed when the two strategies were combined.
机译：这项研究的目的是在涉及大鼠肾下主动脉闭塞的局部缺血模型中，评估抗氧化剂别嘌呤醇和局部缺血后处理对局部缺血再注入（I / R）的有害影响。将动物随机分为五组：（A）不进行局部缺血的动物; （B）仅经历2小时缺血和再灌注的动物一次; （C）通过管饲法给予别嘌呤醇剂量的动物，然后进行2小时的局部缺血和再灌注一次; （D）经历2小时缺血和后处理的动物，以及（E）接受别嘌呤醇，然后经历2小时缺血和后处理的动物。 3天后收集血样和小肠段用于分析。通过测量天冬氨酸转氨酶，丙氨酸转氨酶和乳酸水平，观察了使用别嘌呤醇和缺血后处理的保护作用。从总抗氧化能力和肌酐水平可以明显看出后处理的好处，但是这些不能确定别嘌呤醇的任何积极作用。肠系膜的组织学分析表明，两种方法均能有效减少缺血和再灌注过程的有害影响。个体方案显着减少了I / R系统性损伤，但是当两种策略组合使用时，未观察到额外的保护。

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