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Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk?

机译：他汀类药物治疗和成年女性患糖尿病的风险：益处是否超过风险？

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The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review. The literature contains reports of new-onset diabetes associated with statin use. While many studies do not report sex-specific results, there is evidence indicating the risk to benefit ratio may vary by gender. However, the absolute effects are not clear because women have historically been under-represented in clinical trials. A review of the literature indicates that the cardiovascular benefits of statins appear to outweigh the risk for statin-related diabetes. However, the effect may depend upon baseline diabetes risk, dose, and statin potency. Rigorous, long-term studies focused on the risks and benefits of statins in women are unavailable to sort for gender-specific differences. Until this changes, individualized attention to risk assessment, and strong prevention with lifestyle changes must prevail.
机译：这项审查的目的是使用选择性审查来检查他汀类药物治疗和成年女性患糖尿病的风险。文献中包含与他汀类药物相关的新发糖尿病的报道。尽管许多研究没有报告针对性别的结果，但有证据表明，受益风险比可能因性别而异。但是，由于在历史上妇女在临床试验中的代表性不足，因此绝对作用尚不清楚。文献综述表明，他汀类药物在心血管方面的益处似乎超过了他汀类药物相关糖尿病的风险。但是，效果可能取决于基线糖尿病风险，剂量和他汀类药物的效力。未能针对女性他汀类药物的风险和益处进行严格的长期研究，无法针对性别差异进行分类。在此之前，必须优先注意风险评估，并通过生活方式的改变进行有效的预防。

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