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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Serum chemerin and high-sensitivity C reactive protein as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes
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Serum chemerin and high-sensitivity C reactive protein as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes

机译：埃及2型糖尿病患者血清凯莫瑞和高敏C反应蛋白是亚临床动脉粥样硬化的标志物

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Chemerin is one of the adipokines that regulate fat metabolism. High-sensitivity C-reactive protein (hs-CRP) may be considered as a cardiovascular risk predictor. Measuring intima-media thickness of the CCA (C-IMT) is a well-evidenced tool for the detection of early stages of atherosclerosis. We aimed here to study both serum chemerin and hs-CRP as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes, who are angiographically free of coronary artery disease (CAD). This cross-sectional study was conducted on 180 subjects divided into two groups: Group A included 90 type 2 diabetic patients without CAD and group B including 90 nondiabetic control subjects. All study subjects were having normal coronary angiography. Serum chemerin, homeostasis model assessment for insulin resistance (HOMA-IR), glycated haemoglobin (HbA1c), lipid profile, hs-CRP as well as C-IMT were assessed in all study subjects. There was a statistically significant difference between the 2 groups regarding serum chemerin level, HOMA-IR, hs-CRP and C-IMT; being higher in the diabetic patients than in the control group (p = 0.006, 0.024, 0.040 and p = 0.006 and 0.032, respectively), and negatively correlated with HDL-cholesterol level (p = 0.018). Both serum chemerin and hs-CRP could be considered as markers of subclinical atherosclerosis, and hence, may be utilized for the early detection of macrovascular disease, in Egyptian patients with type 2 diabetes.
机译：Chemerin是调节脂肪代谢的脂肪因子之一。高敏C反应蛋白（hs-CRP）可被认为是心血管疾病的危险因素。测量CCA的中膜中膜厚度（C-IMT）是一种用于早期发现动脉粥样硬化的可靠工具。我们的目的是在埃及2型糖尿病患者中研究血清chemerin和hs-CRP作为亚临床动脉粥样硬化的标志物，这些患者在血管造影上无冠心病（CAD）。这项横断面研究针对分为两组的180位受试者进行：A组包括90位无CAD的2型糖尿病患者，B组包括90位非糖尿病对照受试者。所有研究对象的冠状动脉造影均正常。在所有研究对象中评估了血清凯莫瑞，胰岛素抵抗的稳态模型评估（HOMA-IR），糖化血红蛋白（HbA1c），脂质分布，hs-CRP和C-IMT。两组之间血清凯莫瑞水平，HOMA-IR，hs-CRP和C-IMT差异有统计学意义。糖尿病患者的血糖高于对照组（分别为p = 0.006、0.024、0.040和p = 0.006和0.032），并且与HDL胆固醇水平呈负相关（p = 0.018）。血清chemerin和hs-CRP均可被视为亚临床动脉粥样硬化的标志物，因此可用于埃及2型糖尿病患者的大血管疾病的早期检测。

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