...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid
【24h】

Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid

机译：肥胖非糖尿病患者的血清尿酸水平与体内稳态模型评估相关：HOMA和尿酸

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid. The aim of this study was to evaluate whether there is a correlation between serum uric acid levels with homeostatic model assessment (HOMA) 1 in nondiabetic patients. We evaluated 88 nondiabetic patients, in whom uric acid levels were measured, in all of them HOMA of β-cell function (HOMA 1B) and HOMA of insulin resistance (HOMA 1IR) scores were performed. Uric acid and the HOMA 1 values were correlated using the Pearson coefficient. We did not find any correlation between uric acid levels with both HOMA 1B (r = 0.102, p = 0.343), nor with HOMA 1IR (r = 0.158, p = 0.117). When patients were analyzed by sex, we found a significant correlation with HOMA 1IR (0.278, p = 0.01), but not with HOMA 1B (0.138, p = 0.257) in women. We found a correlation with HOMA 1B in men (r = 0.37, p = 0.044), but not with HOMA 1IR: 0.203, p = 0.283. The analysis performed based on body mass index did not show correlation in the patients with normal weight, (HOMA 1B r = 0.08, p = 0.5, HOMA 1IR = 0.034, p = 0.793), nor in the patients who were overweight (HOMA 1B: r = 0.05, p = 0.76, HOMA 1IR r = 0.145, p = 0.43). However, a significant correlation between uricemia with both HOMA 1B (0.559, p p 0.05), was observed in obese patients. Our results suggest that serum uric acid levels seem to be associated with insulin resistance in women, and in obese patients, but not in nonobese men. Uric acid also modifies β-cell function in men and in obese patients.
机译：高尿酸血症导致胰岛素抵抗，而胰岛素抵抗减少尿酸的肾脏排泄。这项研究的目的是评估非糖尿病患者的血清尿酸水平与稳态模型评估（HOMA）1是否相关。我们评估了88位非糖尿病患者的尿酸水平，所有患者均进行了β细胞功能HOMA（HOMA 1B）和胰岛素抵抗HOMA（HOMA 1IR）评分。使用皮尔森系数将尿酸和HOMA 1值相关。我们没有发现HOMA 1B（r = 0.102，p = 0.343）和HOMA 1IR（r = 0.158，p = 0.117）两者之间的尿酸水平之间没有任何相关性。通过性别对患者进行分析时，我们发现女性与HOMA 1IR（0.278，p = 0.01）有显着相关性，而与HOMA 1B（0.138，p = 0.257）没有显着相关性。我们发现男性与HOMA 1B相关（r = 0.37，p = 0.044），而与HOMA 1IR没有相关性：0.203，p = 0.283。根据体重指数进行的分析在体重正常的患者（HOMA 1B r = 0.08，p = 0.5，HOMA 1IR = 0.034，p = 0.793）和体重超重的患者（HOMA 1B）中均未显示相关性：r ＝ 0.05，p ＝ 0.76，HOMA 1IR r ＝ 0.145，p ＝ 0.43）。然而，在肥胖患者中，尿毒症与两种HOMA 1B之间存在显着相关性（0.559，p p <0.05）。我们的研究结果表明，女性，肥胖患者的血清尿酸水平似乎与胰岛素抵抗有关，而非肥胖男性则没有。尿酸还会改变男性和肥胖患者的β细胞功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号