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首页> 外文期刊>Tobacco Induced Diseases >Relationship between salivary stress biomarker levels and cigarette smoking in healthy young adults: an exploratory analysis
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Relationship between salivary stress biomarker levels and cigarette smoking in healthy young adults: an exploratory analysis

机译：健康年轻人唾液压力生物标志物水平与吸烟之间的关系：一项探索性分析

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Background This study investigated the relationships among salivary stress biomarkers, cigarette smoking, and mood states. Methods The study population comprised 49 healthy sixth-year dental students at Fukuoka Dental College (39 men, 10 women; age, 23–31 years). Lifetime exposure to smoking was calculated using the Brinkman index (BI). Resting saliva samples were collected, and concentrations of cortisol, secretory immunoglobulin A (SIgA), interleukin (IL)-1β, interleukin-6, and tumor necrosis factor (TNF)-α were determined. Mood states (tension-anxiety, depression-dejection, anger-hostility, fatigue, confusion, and vigor) over the previous week were assessed using the Profile of Mood States - Brief Japanese Version. Results Salivary IL-1β levels were significantly higher in smokers than non-smokers ( P =?0.044), regardless of the BI or mood state. A significant positive correlation was evident between the TNF-α level and the BI ( P =?0.036), and the SIgA level was positively correlated with the BI ( P =?0.067) but did not reach statistical significance. In terms of mood states, higher fatigue scores and lower vigor scores were observed in smokers. The TNF-α level and vigor score were negatively correlated ( r =?–0.229, P =?0.135), but the correlation did not reach statistical significance. However, the SIgA level and fatigue score were significantly positively correlated ( r =?0.410, P =?0.005). Conclusions The TNF-α and SIgA levels were both positively correlated with the BI. Furthermore, the TNF-α level was negatively correlated with the vigor score, whereas the SIgA level was positively correlated with the fatigue score. Thus, salivary levels of TNF-α and SIgA may be used as biomarkers of mood states in healthy young smokers.
机译：背景本研究调查了唾液压力生物标志物，吸烟和情绪状态之间的关系。方法研究人群包括福冈牙科大学的49名健康的6年级牙科学生（男39例，女10例;年龄23-31岁）。使用Brinkman指数（BI）计算终身吸烟。收集静止的唾液样品，并测定皮质醇，分泌性免疫球蛋白A（SIgA），白介素（IL）-1β，白介素-6和肿瘤坏死因子（TNF）-α的浓度。使用情绪状态简介-简明日语版评估了过去一周的情绪状态（紧张，焦虑，沮丧，沮丧，愤怒，敌对，疲劳，困惑和活力）。结果不论BI或情绪状态如何，吸烟者的唾液IL-1β水平均显着高于非吸烟者（P =？0.044）。 TNF-α水平与BI之间存在显着的正相关（P =？0.036），SIgA水平与BI呈正相关（P =？0.067），但未达到统计学意义。就情绪状态而言，在吸烟者中观察到较高的疲劳评分和较低的活力评分。 TNF-α水平与活力评分呈负相关（r =？– 0.229，P =？0.135），但相关性未达到统计学意义。但是，SIgA水平与疲劳评分显着正相关（r =？0.410，P =？0.005）。结论TNF-α和SIgA水平均与BI呈正相关。此外，TNF-α水平与活力得分呈负相关，而SIgA水平与疲劳得分呈正相关。因此，唾液中的TNF-α和SIgA水平可用作健康的年轻吸烟者情绪状态的生物标志物。

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