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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >The Effects of Melatonin on the Relationship between Air Pollution Levels and Biomarkers of Oxidative Stress and Platelet Activation in Healthy Young Adults
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The Effects of Melatonin on the Relationship between Air Pollution Levels and Biomarkers of Oxidative Stress and Platelet Activation in Healthy Young Adults

机译：褪黑素对健康成年人空气污染水平与氧化应激和血小板活化生物标志物之间关系的影响

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Urinary free malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as biomarkers of oxidative stress as well as soluble P-selectin as a biomarker of platelet activation have been associated with air pollution exposure. However, the results have not been consistent across studies. We hypothesize that this inconsistency might be due to modification of circulating melatonin, a free radical scavenger and a key factor in the DNA damage repair system, on MDA and 8-OHdG responses to reactive oxygen species induced by air pollution exposure. Melatonin also regulates PPARv/FUNDCl/ mitophagy pathways, hence affecting P-selectin level. We conducted a longitudinal study involving 70 healthy young adults living on a hospital campus in Shanghai. Indoor and outdoor PM2.5, O3, and NO2 were monitored throughout the study and combined with time activity pattern to estimate personal air pollution exposure. The results show that a 10% increase of urinary 6-sulfatoxymelatonin (aMT6s, a major metabolite of melatonin and highly correlated with circulating melatonin) was associated with a significant increase in urinary 8-OHdG by 2.4% [95% CI: 1.4%, 3.4%] and a significant decrease in urinary free MDA and soluble P-selectin by -1.5% [-2.4%, -0.6%] and -1.0% (-1.9%, -0.1%], respectively. Compared to unadjusted models (specified in parenthesis), models with urinary aMT6s as an effect modifier showed that 10 μg/m3 in PM2.5 12h personal exposure was associated with a change in urinary 8-OHdG by 11.0% [-2.4%, 24.3%] (unadjusted: -3.8% [-7.4%, -0.2%]), a change in urinary free MDA by 14.0% [2.4%, 25.7%] (unadjusted: -0.3% [-3.4%, 2.8%]), and 10 μg/m3 increase in NO2 12h personal exposure was associated with a change in P-selectin by 5.4% [-10.2%, 21.0%] (unadjusted: -5.3% [-9.5%, -1.1%]). Similar mediation effects were also observed for 03. These findings support the role of melatonin as a mediator for oxidative stress and platelet activation introduced by air pollution exposure.
机译：尿中的游离丙二醛（MDA）和8-羟基-2'-脱氧鸟苷（8-OHdG）作为氧化应激的生物标志物以及可溶性P-选择素作为血小板活化的生物标志物已与空气污染暴露相关。但是，研究结果不一致。我们假设这种不一致可能是由于循环褪黑激素，自由基清除剂和DNA损伤修复系统中的关键因素的修饰导致的，MDA和8-OHdG对暴露于空气污染引起的活性氧的反应。褪黑激素还调节PPARv / FUNDCl /线粒体吞噬途径，从而影响P-选择素水平。我们进行了一项纵向研究，研究对象包括居住在上海医院校园内的70名健康的年轻人。在整个研究过程中，对室内和室外的PM2.5，O3和NO2进行监测，并与时间活动模式结合以估算个人空气污染暴露程度。结果表明，尿中6-硫酸酯化褪黑激素（aMT6s是褪黑激素的主要代谢产物，与循环褪黑激素高度相关）增加10％与尿中的8-OHdG显着增加2.4％相关[95％CI：1.4％，与未经调整的模型相比，尿中的游离MDA和可溶性P-选择素分别降低了-1.5％[-2.4％，-0.6％]和-1.0％（-1.9％，-0.1％）。在括号中指定），以尿液aMT6s为效果调节剂的模型显示，PM2.5 12h个人暴露量中10μg/ m3与尿液中8-OHdG的变化有关，变化幅度为11.0％[-2.4％，24.3％]（未经调整： -3.8％[-7.4％，-0.2％]），尿中游离MDA变化14.0％[2.4％，25.7％]（未调整：-0.3％[-3.4％，2.8％]）和10μg/ NO3在12h个人暴露中的m3增加与P-选择素变化5.4％[-10.2％，21.0％]（未调整：-5.3％[-9.5％，-1.1％]）相关，也观察到类似的调解作用对于03。这些发现支持褪黑激素作为介体的作用用于暴露于空气污染中的氧化应激和血小板活化。

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