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首页> 外文期刊>Toxicology Reports >Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation
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Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

机译：香兰素通过调节胃液分泌，氧化应激和炎症消除乙醇对大鼠的胃损伤

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Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied in experimental gastric ulcer. Gastric secretion and acidity were studied in pylorus ligated rats. Ulcer index, levels of gastric mucus, malondialdehyde (MDA), myeloperoxidase activity (MPO), expression of nuclear factor kappa B (NF-@kB) p65, and histopathological changes were determined in ethanol induced gastric ulcer. Pre treatment with vanillin significantly reduced gastric secretion (P<0.001) and acidity (P<0.0001) and gastric ulcer index scores (P<0.001). and augmented the gastric mucosal defense. Vanillin significantly restored the depleted gastric wall mucus levels (P<0.0001) induced by ethanol and also significantly attenuated ethanol induced inflammation and oxidative stress by the suppression of gastric MPO activity (P<0.001), reducing the expression of NF-@kB p65 and the increased MDA levels (P<0.001). Vanillin was also effective in alleviating the damage to the histological architecture and the activation of mast cells induced by ethanol. Together the results of this study highlight the gastroprotective activity of vanillin in gastric ulcers of rats through multiple actions that include inhibition of gastric secretion and acidity, reduction of inflammation and oxidative stress, suppression of expression of NF-@kB, and restoration of the histological architecture.
机译：香兰素通常在食品，药品和化妆品中用作添加剂，但尚未在胃损伤中研究其作用。因此，研究了香兰素在实验性胃溃疡中的作用。在幽门结扎的大鼠中研究胃分泌和酸度。测定乙醇诱发的胃溃疡的溃疡指数，胃粘液水平，丙二醛（MDA），髓过氧化物酶活性（MPO），核因子κB（NF-kB）p65的表达以及组织病理学变化。香草醛预处理可显着降低胃液分泌（P <0.001）和酸度（P <0.0001）和胃溃疡指数评分（P <0.001）。并增强了胃黏膜的防御能力。香兰素可通过抑制胃MPO活性（P <0.001）显着恢复乙醇诱导的耗尽的胃壁粘液水平（P <0.0001），并显着减轻乙醇诱导的炎症和氧化应激（P <0.001），从而降低NF- @ kB p65和MDA水平升高（P <0.001）。香兰素在减轻乙醇引起的组织结构损伤和肥大细胞活化方面也有效。这项研究的结果共同强调了香兰素在大鼠胃溃疡中的胃保护活性，它通过多种作用包括抑制胃液分泌和酸度，减少炎症和氧化应激，抑制NF-kB的表达以及恢复组织学。建筑。

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