Malignancy grading of invasive fronts of oral squamous cell carcinomas: Correlation with overall survival

Upul Dissanayake

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Malignancy grading of invasive fronts of oral squamous cell carcinomas: Correlation with overall survival

机译：口腔鳞状细胞癌浸润性前沿的恶性分级：与总生存期的关系

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Background:Clinical stage and pathology grading have consistently failed to predict survival in patients diagnosed with oral squamous cell carcinoma (OSCC). There is a need to develop a grading system that could have a predictive value in assessing the prognosis of patients with OSCC. The aim was to evaluate the prognostic significance of several parameters of the modified Bryne’s malignancy grading system.Methods:Malignancy grading of invasive fronts of 60 OSCCs from Sri Lankan subjects was undertaken using Bryne’s criteria.Results:Of the five morphological features assessed at the invasive fronts of the tumours, the range of scores derived for keratinization was low, and the host response in the stromal tissue was marked compared with reported series from European countries. There were no tumours scoring a malignancy grading under 9, regarded as tumours with a ‘good prognosis’. In logistic regression analysis among patient factors, age had a positive association on survival, and among tumour factors, th...

机译：背景：临床分期和病理分级一直未能预测诊断为口腔鳞状细胞癌（OSCC）的患者的存活率。需要开发一种分级系统，该分级系统在评估OSCC患者的预后时可能具有预测价值。目的：评价改良的Bryne恶性分级系统的几个参数的预后意义。方法：采用Bryne标准对斯里兰卡60例OSCC的浸润前线进行恶性分级。结果：在浸润后评估的五个形态学特征与欧洲国家报道的系列相比，在肿瘤的最前沿，角质化得分范围很低，并且基质组织中的宿主反应也很明显。没有肿瘤的恶性评分低于9，被认为是“预后良好”的肿瘤。在患者因素之间的逻辑回归分析中，年龄与生存率呈正相关，而在肿瘤因素之间，...

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《Translational Research in Oral Oncology》 |2017年第1期|共页
作者
Upul Dissanayake;
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中图分类肿瘤学;
关键词
Oral cancerprognosismalignancy gradinginvasive front;

机译：口腔癌预后肿瘤分级浸润前;

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1. Malignancy grading of invasive fronts of oral squamous cell carcinomas: Correlation with overall survival [J] . Upul Dissanayake Translational Research in Oral Oncology . 2017,第1期

机译：口腔鳞状细胞癌浸润性前沿的恶性分级：与总生存期的关系
2. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. [J] . Kurokawa H, Zhang M, Matsumoto S, Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology . 2006,第5期

机译：口腔鳞状细胞癌中，syndecan-1表达的降低与深部浸润前部的恶性组织学等级相关。
3. Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas [J] . J Piffkò, A Bànkfalvi, D ?fner, British Journal of Cancer . 1997,第10期

机译：在口腔鳞状细胞癌浸润性肿瘤前评估组织生物学因素（恶性分级和AgNOR含量）的预后价值
4. Discovering oral squamous cell carcinoma biomarkers via novel, non-invasive in-situ oral lesion exudates and proteomic analysis [C] . Joel Kooren, Chuanning Tang, Nelson Rhodus, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过新颖，非侵入性原位口腔病变渗出物和蛋白质组学分析，发现口腔鳞状细胞癌生物标志物
5. The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma. [D] . Anand, Sumeet M. 2009

机译：口腔和口咽鳞状细胞癌的肿瘤体积与生存率的关系。
6. Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas. [O] . J. PiffkÃ², A. BÃ nkfalvi, D. Ofner, 1997

机译：在口腔鳞状细胞癌的浸润性肿瘤前评估组织生物学因素（恶性分级和AgNOR含量）的预后价值。
7. Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas. [O] . PiffkÃ², J., BÃ nkfalvi, A., Ofner, D., 1997

机译：在口腔鳞状细胞癌的浸润性肿瘤前评估组织生物学因素（恶性分级和AgNOR含量）的预后价值。

Malignancy grading of invasive fronts of oral squamous cell carcinomas: Correlation with overall survival

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