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Acute Methemoglobinemia

机译:急性血红蛋白血症

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A young newly married couple was presented to us in cyanosis following ingestion of a poisonous substance which had nitrobenzene in it. Initially on examination they were conscious and hemodynamically stable but, later on became unconscious with altered respiratory pattern, hypotension which was resistant to inotropic agents with deranged renal function. Exchange transfusion was attempted but could not avoid the fatality. Case Report A young couple presented to us in altered sensorium after ingestion of an unknown substance 48 hours back. They initially had nausea and multiple episodes of vomiting, and after 24 hours they became drowsy and respiratory rate increased. On presentation, both of them had central cyanosis, respiratory rates were between 25-30/min, pupils were normal size reacting to light, with an almond like odor in their breaths and were hemodynamically stable. Analysis of the ingested substance revealed Nitrobenzene in it. Further examination of the blood sample on a filter paper was done, and it appeared dark brown in color, thereby a diagnosis of acute methemoglobinemia was made. Arterial blood gas analysis of both the patients were carried out which showed nearly similar values suggestive of compensated metabolic acidosis (Table 1).
机译:一对年轻夫妇在摄入含有硝基苯的有毒物质后出现紫。最初检查时它们是有意识的并且血液动力学稳定,但后来由于呼吸模式改变而变得无意识,低血压可抵抗肾功能异常的正性肌力药。尝试进行输血,但无法避免死亡。病例报告一对年轻夫妇在48小时后摄入未知物质后,在感觉上发生改变。他们最初有恶心和多次呕吐发作,并且在24小时后变得昏昏欲睡,呼吸频率增加。呈现时,他们俩都有中枢性紫cyan,呼吸频率在25-30 / min之间,瞳孔大小正常,对光有反应,呼吸中有杏仁味,血液动力学稳定。对摄入物质的分析表明其中含有硝基苯。在滤纸上进一步检查血样,其颜色显示为深褐色,从而诊断为急性高铁血红蛋白血症。两名患者的动脉血气分析均显示出近似相似的值,提示代偿性代谢性酸中毒(表1)。

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