• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Internet Journal of Emergency and Intensive Care Medicine >Ibuprofen vs Acetaminophen Comparison on Stool Output in Children with Febrile Diarrhea
【24h】

Ibuprofen vs Acetaminophen Comparison on Stool Output in Children with Febrile Diarrhea

机译：布洛芬与对乙酰氨基酚治疗高热性腹泻儿童粪便量的比较

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective:To determine the efficacy of Ibuprofen in treating febrile diarrheas as compared to Acetaminophen in terms of reduction of the number of loose stools and decrease in the occurrence of dehydration regardless of the etiology of febrile diarrhea.Hypothesis:Ibuprofen, as compared to Acetaminophen in the treatment of febrile gastroenteritis, will be more efficacious in reducing the number of stools and preventing dehydration.Hypothesis was based on the fact that ibuprofen inhibits prostaglandins.MethodsChildren between the ages of 4 months and 6 years who presented with febrile diarrhea and met the criteria were enrolled in the study. All enrollees were randomly divided into two groups A (Acetaminophen) and B (Ibuprofen) and treated for 24 hours. They received a double-blinded suspension of either Acetaminophen or Ibuprofen during the study period. The parents were given prescriptions for Pedialyte for one day. The patients were recalled after 24 hours to the emergency room. The number of loose stools since last visit and status of hydration was reassessed. In addition, patients were examined and assessed for any possible side effects of the medications. Decrease in number of stools 24 hours later following the initial visit, was taken as the primary outcome measure for the study.ResultsA total of 84 patients were enrolled into the study. Both drug categories had 42 (50%) enrollees. Two patients were lost to follow up in each group. The average number of stools on the first visit (day 1) in group A (Acetaminophen) was 5.12 and the average number of stools in group B (ibuprofen) was 5.25. Twenty-four hours later, the average number of stools, in group A was 3.45 (1-5) and the average number of stool in group B, was 1.9 (0-4). The two-tailed p-value was< 0.0001 with a confidence interval at 95% (1.44-2.6).Conclusions:This prospective randomized, double blind clinical trial showed a significant decrease in the number of stools between Ibuprofen and Acetaminophen in the treatment of febrile diarrheas as hypothesized. Introduction Diarrheas are caused by various infectious agents such as viruses, bacteria and fungi, or nutritional or psychological étiologies1-11.The acute febrile diarrheal illnesses are usually caused by viruses and or toxin producing bacteria1, 2. The consequences of diarrhea are fluid and electrolyte losses resulting in various degrees of dehydration 5, 6; Mild stages of dehydration are usually managed by giving plenty of liquids by mouth for twenty four hours 6 and later advancing to BRAT (Banana, rice, apple sauce and toast of bread) diet (Duro Deborah and Dugaan Christoper, 2007). Patients with moderate to severe dehydration are usually admitted into the hospital for intravenous hydration. Prostaglandins (PG) and cyclic AMP stimulate intestinal secretions12. PGE and PGF facilitate movements of water and electrolytes into the intestinal lumen. Diarrheal diseases are associated with increased production of PGE and PGF13. Enteric pathogens increase secretion of fluid by increased stimulation of prostaglandin synthesis14. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDS) such as indomethacin and ibuprofen cause inhibition of adenylate cyclase, which decreases cyclic AMP resulting in reduction of secretions and increase in absorption of fluids13,15. We hypothesized that Ibuprofen, when compared to acetaminophen in the treatment of febrile diarrhea, will be more efficacious in reducing the number of loose stools and preventing or reducing dehydration.This prospective randomized double blind study was conducted to determine the efficacy of Ibuprofen in patients with febrile diarrheas as compared to Acetaminophen as evidenced by the decrease in the number of loose stools as the criterion. Materials and Methods Study DesignThis is a prospective randomized double blind clinical study, approved by the NYMC Institution Review Board and also by the NYCHHC Research committee. IRB # L6370)Study Setting an
机译：目的：从减少粪便数量和减少脱水发生的角度出发，确定布洛芬与对乙酰氨基酚相比在治疗高热腹泻中的有效性。假说是基于布洛芬抑制前列腺素的事实。方法4个月至6岁之间出现高热腹泻并符合标准的儿童被纳入研究。将所有入选者随机分为A组（对乙酰氨基酚）和B组（布洛芬），治疗24小时。在研究期间，他们接受了对乙酰氨基酚或布洛芬的双盲悬浮液。给父母开了一天的Pedialyte处方。 24小时后将患者召回急诊室。重新评估自上次就诊以来的稀便数量和水合状况。另外，检查和评估患者药物的任何可能的副作用。首次就诊后24小时，粪便数量的减少是该研究的主要结局指标。结果共有84例患者入选该研究。两种药物类别都有42（50％）名参加者。每组有两名患者失访。 A组（对乙酰氨基酚）第一次就诊（第1天）的平均粪便数量为5.12，B组（布洛芬）的平均粪便数量为5.25。 24小时后，A组的平均粪便数量为3.45（1-5），B组的平均粪便数量为1.9（0-4）。双尾p值<0.0001，置信区间为95％（1.44-2.6）。结论：该前瞻性随机双盲临床试验显示，布洛芬和对乙酰氨基酚之间的粪便数量显着减少。假设有高热性腹泻。前言腹泻是由多种传染原引起的，例如病毒，细菌和真菌，或营养或心理病因1-11。急性发热性腹泻病通常是由病毒和/或产生毒素的细菌1、2引起的。腹泻的后果是体液和电解质造成不同程度脱水的损失5、6;轻度的脱水通常是通过口服大量液体来进行的，持续时间为二十四小时6，然后逐渐采用BRAT（香蕉，米，苹果酱和面包吐司）饮食（Duro Deborah和Dugaan Christoper，2007年）。中度至重度脱水的患者通常会入院进行静脉补液。前列腺素（PG）和环状AMP刺激肠道分泌物12。 PGE和PGF促进水和电解质向肠腔的运动。腹泻疾病与PGE和PGF13的产生增加有关。肠道病原体通过增加前列腺素合成的刺激来增加体液分泌14。阿司匹林和其他非甾体抗炎药（如吲哚美辛和布洛芬）会抑制腺苷酸环化酶，从而降低环AMP含量，从而导致分泌减少并吸收液体13,15。我们假设布洛芬与对乙酰氨基酚相比在治疗高热性腹泻时会更有效地减少稀便的数量并预防或减少脱水。这项前瞻性随机双盲研究旨在确定布洛芬在患有发热性腹泻的患者中的疗效。与对乙酰氨基酚相比，高热性腹泻是通过减少稀便的数量作为标准来证明的。材料和方法研究设计这是一项前瞻性随机双盲临床研究，已获得NYMC机构审查委员会和NYCHHC研究委员会的批准。 IRB＃L6370）研究设置

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号