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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Effectiveness and safety of Compound Danshen injection as treatment for pregnancy-induced hypertension: A meta-analysis
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Effectiveness and safety of Compound Danshen injection as treatment for pregnancy-induced hypertension: A meta-analysis

机译：复方丹参注射液治疗妊娠高血压综合征的有效性和安全性的荟萃分析

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Purpose: To systematically evaluate the effectiveness and safety of Compound Danshen injection in patients with pregnancy-induced hypertension (PIH). Methods: PubMed, Embase, Cochrane Library, Chinese biomedical literature database (CBM), VIP (xiAn), China National Knowledge Infrastructure (CNKI) and Wan Fang databases were searched up to March 20, 2018, for all randomized controlled trials (RCTs) on the use of Compound Danshen injection in patients with PIH. Data were extracted from included studies after assessing the quality of literature. Revman 5.3 software was used for statistical analysisA294; Results: A total of 18 RCTs involving 1735 patients were included. The results of meta-analysis indicated that the study group was superior to the control group in clinical effectiveness (RR = 1.15, 95 % CI: 1.02 - 1.30); intrauterine fetal distress (RR = 0.26, 95 % CI: 0.09 - 0.70); cesarean section (RR = 0.72, 95 % CI: 0.58 - 0.90), and neonatal asphyxia (RR = 0.23, 95 % CI: 0.11 - 0.48). There were no statistical differences in fetal heart rate abnormalities (RR = 0.58, 95 %, CI: 0.33 - 1.02, p 0.05) and postpartum hemorrhage (RR = 0.86, 95 % CI: 0.53 - 1.42) between the two groups. Conclusion: Treatment of PIH with Compound Danshen injection (alone or in combination) is superior to the use of conventional western medical treatment in safety and effectiveness. However, higher quality clinical studies are needed to confirm these results because most trials included in this study were of low quality.
机译：目的：系统评价复方丹参注射液在妊娠高血压综合征（PIH）患者中的有效性和安全性。方法：截至2018年3月20日，检索PubMed，Embase，Cochrane图书馆，中国生物医学文献数据库（CBM），VIP（西安），中国国家知识基础设施（CNKI）和万芳数据库，以获取所有随机对照试验（RCT）。复方丹参注射液在PIH患者中的应用研究在评估文献质量之后，从纳入的研究中提取数据。使用Revman 5.3软件进行统计分析。结果：共纳入18项RCT，涉及1735名患者。荟萃分析的结果表明，研究组的临床疗效优于对照组（RR = 1.15，95％CI：1.02-1.30）;宫内胎儿窘迫（RR = 0.26，95％CI：0.09-0.70）;剖宫产（RR = 0.72，95％CI：0.58-0.90）和新生儿窒息（RR = 0.23，95％CI：0.11-0.48）。两组的胎儿心率异常（RR = 0.58，95％，CI：0.33-1.02，p> 0.05）和产后出血（RR = 0.86，95％CI：0.53-1.42）之间无统计学差异。结论：复方丹参注射液（单独或联合使用）治疗PIH在安全性和有效性方面优于常规西药治疗。但是，需要较高质量的临床研究来证实这些结果，因为该研究中包括的大多数试验都是低质量的。

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