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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Antioxidant properties, selected enzyme inhibition capacities, and a cosmetic cream formulation of Thai mango seed kernel extracts
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Antioxidant properties, selected enzyme inhibition capacities, and a cosmetic cream formulation of Thai mango seed kernel extracts

机译：抗氧化剂特性，选定的酶抑制能力以及泰国芒果籽仁提取物的美容霜配方

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Purpose: To investigate the antioxidant properties, the inhibition of selected enzyme activities of ultrasonication-assisted mango seed kernel extract (MSKE), and to evaluate the physical stability and skin irritation properties of a cosmetic cream formulated with MSKE. Methods: Choke-Anan MSKE and a Kaew cultivar of Thai mangoes were prepared by ultrasonication-assisted extraction. Antioxidant activities (DPPH, FRAP, H 2 O 2 scavenging assay, ABTS), antityrosinase, anti 5-lipoxygenase, antihyaluronidase and anti α-glucosidase were determined. Cosmetic creams containing 0, 1, 2 and 3 % of MSKE were prepared and evaluated for physical stability. The most stable formulation was subjected to the clinical skin irritation test. Results: The yield, total polyphenol content, antioxidant properties and inhibition of 5-lipoxygenase, hyaluronidase and α-glucosidase were higher (p 0.05) in tyrosinase inhibition activity compared to arbutin. However, a slightly lower α-glucosidase inhibition activity than acarbose was observed. The cosmetic cream containing 1 % Choke-Anan MSKE had good physical stability with no skin irritation. Conclusion: MSKE exhibits good antioxidant and enzyme inhibitory activity. Thus, it is a potentially natural functional ingredient for use in food and cosmetic industries.
机译：目的：研究超声辅助芒果籽仁提取物（MSKE）的抗氧化性能，对所选酶活性的抑制作用，并评估用MSKE配制的美容霜的物理稳定性和皮肤刺激性。方法：采用超声辅助提取法制备Ch节安南MSKE和泰国芒果的Kaew品种。测定抗氧化活性（DPPH，FRAP，H 2 O 2清除测定，ABTS），抗酪氨酸酶，抗5-脂氧合酶，抗透明质酸酶和抗α-葡萄糖苷酶。制备含有0、1、2和3％MSKE的美容霜，并评估其物理稳定性。最稳定的制剂经过临床皮肤刺激试验。结果：与熊果苷相比，酪氨酸酶的抑制活性更高（p <0.05），对5-脂氧合酶，透明质酸酶和α-葡萄糖苷酶的产量，总多酚含量，抗氧化性能和抑制作用更高。然而，观察到α-葡萄糖苷酶的抑制活性比阿卡波糖略低。含有1％Choke-Anan MSKE的美容霜具有良好的物理稳定性，不会刺激皮肤。结论：MSKE具有良好的抗氧化和酶抑制活性。因此，它是用于食品和化妆品工业的潜在天然功能成分。

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