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首页> 外文期刊>Trials >Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial
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Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial

机译：短期补充精氨酰果糖对糖尿病前期患者和新诊断的2型糖尿病患者的降血糖作用：随机，双盲，安慰剂对照试验

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Background A previous study reported that arginyl-fructose may have great value as a functional food with antioxidant and antidiabetic activities. However, there have been few clinical studies on the efficacy of arginyl-fructose supplementation for blood glucose control. Methods In this double-blind, placebo-controlled study, 60 Korean subjects with prediabetes or type 2 diabetes mellitus were randomly assigned to placebo or test groups. The test group subjects received 1500?mg/day arginyl-fructose. Fasting serum levels of glucose, hemoglobin A1c, insulin, and free fatty acids were measured by 2-hour oral glucose tolerance tests at baseline and after the 6-week intervention. Eleven subjects dropped out or were excluded during the trial. The data for the remaining 49 were statistically analyzed using Student’s t -test and paired t -test. Results After the 6-week intervention, the test group showed significant reductions in serum glucose levels at 30?minutes (?19.4?±?5.62?mg/dL) and 60?minutes (?15.4?±?7.01?mg/dL) and reduced glucose area under the curve (?27.4?±?8.59?mg/dL) compared with those of the placebo control group. The changes (differences from baseline) in serum glucose levels at 60?minutes and glucose area under the curve in the test group differed significantly from those in the control group even after adjusting for baseline values. In contrast, glucose-related biomarkers including hemoglobin A1c, insulin, and C-peptide levels were not significantly improved by the dietary intervention with arginyl-fructose. Conclusions Arginyl-fructose supplementation (1500?mg/day) may be beneficial for reducing postprandial blood glucose levels in patients with prediabetes or type 2 diabetes mellitus. Trial registration ClinicalTrials.gov NCT02285231 . Registered 11 May 2014.
机译：背景技术先前的研究报道，精氨酸果糖作为具有抗氧化和抗糖尿病活性的功能性食品可能具有巨大的价值。然而，很少有临床研究关于精氨酰果糖补充剂对血糖控制的功效。方法在这项双盲，安慰剂对照研究中，将60名韩国患有糖尿病前期或2型糖尿病的受试者随机分配至安慰剂或试验组。测试组受试者每天接受1500？mg的精氨酰果糖。空腹血清葡萄糖，血红蛋白A1c，胰岛素和游离脂肪酸的水平在基线和干预6周后通过2小时口服葡萄糖耐量测试来测量。 11名受试者退出试验或被排除在试验之外。使用学生的t检验和配对t检验对其余49个数据进行统计分析。结果经过6周的干预，测试组在30分钟（？19.4？±？5.62？mg / dL）和60分钟（？15.4？±？7.01？mg / dL）的血糖水平显着降低。与安慰剂对照组相比，曲线下的葡萄糖面积减少（？27.4±±？8.59？mg / dL）。即使在调整基线值之后，测试组在60分钟的血糖水平变化和曲线下的葡萄糖面积的变化（与基线的差异）与对照组也有显着差异。相反，精氨酸果糖的饮食干预并未明显改善包括血红蛋白A1c，胰岛素和C肽水平在内的葡萄糖相关生物标志物。结论每天补充1500毫克精氨酸果糖可能有助于降低糖尿病前期或2型糖尿病患者的餐后血糖水平。试用注册ClinicalTrials.gov NCT02285231。 2014年5月11日注册。

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