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首页> 外文期刊>Veterinarski glasnik >Arcanobacterium pyogenes: Virulence factors, importance in mastitis etiology and therapeutic (im)possibilities
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Arcanobacterium pyogenes: Virulence factors, importance in mastitis etiology and therapeutic (im)possibilities

机译：化脓性产弧菌：毒力因子，在乳腺炎病因中的重要性和治疗（无效）可能性

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摘要

Arcanobacterium pyogenes is an opportunistic pathogen, a causative agent of suppurative infections of organs and tissues in economically important livestock species. Most frequently this bacteria is isolated from inflamed lung lesions in pigs and cattle, in samples of uterine mucus of cows with endometritis and milk from cows with clinical mastitis. A. pyogenes possesses a number of virulence factors: cholesterol-dependent cytolysin (pyolysin), two neuraminidases, several proteases, extracellular matrix-binding proteins, DNases, fimbriae. The virulence factors are well studied in laboratory conditions, but the role of these factors in the pathogenesis of A. pyogenes infections remains to be elucidated. Lately, the ability of A. pyogenes to form biofilm in vivo has also been implicated as a virulence factor and a possible cause of therapeutic failure. Despite the fact that A. pyogenes milk isolates in cows with mastitis in vitro are very sensitive to β-lactam drugs and tetracycline, experience has shown that therapy is usually ineffective, prognosis is poor and the affected quarter is lost for milk production.
机译：化脓性产弧菌是机会病原体，是重要的家畜物种器官和组织化脓性感染的病原体。最常见的是，这种细菌是从猪和牛发炎的肺部病变，患有子宫内膜炎的母牛的子宫粘液样本和患有临床乳腺炎的母牛的牛奶中分离出来的。化脓杆菌具有许多毒力因子：胆固醇依赖性溶血素（溶血素），两种神经氨酸酶，几种蛋白酶，细胞外基质结合蛋白，DNases，菌毛。在实验室条件下对毒力因子进行了充分研究，但是这些因子在化脓性链球菌感染的发病机理中的作用仍有待阐明。最近，化脓性链球菌在体内形成生物膜的能力也被认为是一种毒力因子和治疗失败的可能原因。尽管在体外患有乳腺炎的母牛中，化脓性链球菌牛奶分离物对β-内酰胺类药物和四环素非常敏感，但经验表明，该疗法通常无效，预后差，受影响的四分之一产奶量损失。

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