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首页> 外文期刊>Tuberculosis Research and Treatment >Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes ofMycobacterium tuberculosis
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Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes ofMycobacterium tuberculosis

机译：恶二唑啉和木质素对结核分枝杆菌分支杆菌酸合成及超微结构变化的影响

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摘要

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed againstMycobacterium tuberculosisH37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.
机译：结核病（TB）是一种重要疾病，在世界范围内导致数千人死亡。据报道对抗结核药物有耐药性。因此，需要研究新的有效抗分枝杆菌分子。通过抗分枝杆菌微稀释试验（TEMA）评估了三种木脂素和两种合成two的抗分枝杆菌活性对结核分枝杆菌H37Rv。恶二唑啉（AC451）和木脂素（乙氧基立方体）是活性最高的化合物（MIC 6.09和62.4μm，分别为）。通过质谱分析，用这两种化合物检测了处理过的细菌的霉菌酸谱的一些变化。另外，乙氧基立方蛋白治疗中霉菌酸的减少水平与细菌形态的破坏有关。

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