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The Predictive Role of NEDA in the Long-Term Course of Multiple Sclerosis

机译：NEDA在多发性硬化症长期病程中的预测作用

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Many important developments have occurred in the treatment of multiple sclerosis (MS) in the last two decades. The long-term effects of treatments, except-disease modifying agents such as interferon and glatiramer, are not clear. Studies about the natural course of disease performed during the pre-treatment era showed that approximately half of patients transform to progressive stage in 15 years. The amount of disease-course modifying effects of current treatments is not clear. A cohort study by researchers from the University of California in San Francisco (UCSF) tried to answer this question (1). This was a long-term follow-up study of patients with MS who were under treatment. The study included 517 patients who were being followed up in the MS clinic of UCSF beginning from 2004. The patients were classified into two groups as relapsing MS (RMS) and progressive MS (PMS), and were followed up for 10 years. During this period, Extended Disability Status Scale (EDSS), PASAT-3 for cognitive evaluation, 9-hole peg test for manual dexterity, and the Timed 25 Foot Walk (25-FW) test for leg function were performed regularly and recorded.
机译：在过去的二十年中，在多发性硬化症（MS）的治疗中发生了许多重要的发展。除疾病修饰剂（如干扰素和格拉替雷）外，治疗的长期效果尚不清楚。在治疗前时期进行的有关疾病自然过程的研究表明，大约一半的患者在15年内会转变为进展期。目前治疗疾病过程的效果尚不清楚。加利福尼亚大学旧金山分校（UCSF）的研究人员进行的一项队列研究试图回答这个问题（1）。这是对正在接受治疗的MS患者的长期随访研究。该研究纳入了从2004年开始在UCSF的MS诊所接受随访的517例患者。将患者分为复发性MS（RMS）和进行性MS（PMS）两组，并随访了10年。在此期间，定期进行记录并记录了扩展残疾状态量表（EDSS），用于认知评估的PASAT-3，用于手灵巧性的9孔钉测试和用于腿功能的定时25步步行（25-FW）测试。

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