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首页> 外文期刊>Virology Journal >Bovine ISG15: an antiviral and inducible protein in BIV infected fetal bovine lung cells
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Bovine ISG15: an antiviral and inducible protein in BIV infected fetal bovine lung cells

机译：牛ISG15：BIV感染的胎牛肺细胞中的一种抗病毒和可诱导蛋白

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Bovine ISG15 (bISG15) is an interferon inducible ubiquitin-like protein that is responsible for the establishment of early pregnancy in ruminant, understanding the properties of bISG15 capable of being inducible in fetal bovine lung (FBL) cells upon infection of bovine immunodeficiency virus (BIV) is of significant importance. In this study, we investigated the expression of bISG15 in poly I:C treated FBL cells. The increased expression of bISG15 was observed, and the inhibition of BIV replication was also detected in FBL cells. Elimination of bISG15 expression by small interfering RNA reversed the bISG15 mediated inhibition of BIV replication. These findings demonstrate that bISG15 plays an important role in inhibition of the BIV replication in FBL cells. Furthermore, real-time PCR and western blot assay revealed that bISG15's expression can also be induced in BIV infected FBL cells. Taken together, bISG15 is an antiviral and inducible protein in BIV infected FBL cells.
机译：牛ISG15（bISG15）是一种干扰素诱导型泛素样蛋白，负责在反刍动物中早期妊娠的建立，了解感染牛免疫缺陷病毒（BIV）后能够在胎牛肺（FBL）细胞中诱导的bISG15的特性。 ）非常重要。在这项研究中，我们调查了bISG15在经I：C处理的FBL细胞中的表达。观察到bISG15表达增加，并且在FBL细胞中也检测到BIV复制的抑制。小干扰RNA消除bISG15表达可逆转bISG15介导的BIV复制抑制。这些发现证明bISG15在抑制FBL细胞中的BIV复制中起重要作用。此外，实时PCR和蛋白质印迹分析表明，bISG15的表达也可以在感染BIV的FBL细胞中被诱导。综上所述，bISG15是BIV感染的FBL细胞中的一种抗病毒和可诱导蛋白。

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