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首页> 外文期刊>World Journal of AIDS >Progression of Platelet Counts in Treatment Na?ve HIV/HCV Co-Infection
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Progression of Platelet Counts in Treatment Na?ve HIV/HCV Co-Infection

机译：初次HIV / HCV合并感染治疗中血小板计数的进展

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Background: Previous research has suggested an association between infection with hepatitis C virus (HCV) or with human immunodeficiency virus (HIV) and low platelet counts. This study estimates platelet count changes over time in HIV/HCV co-infected participants and compares them with the changes in platelet count among HIV mono-infected participants to test if HIV/HCV co-infection is associated with lower platelet counts. Methods: This retrospective cohort study included all HIV treatment naive patients from four sites in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort with platelet count measurements between 2002 and 2009. We conducted a mixed effects linear regression modeling the mean change in platelet count per year while adjusting for age, sex, race, baseline CD4 cell count, and site. Index date was the first platelet count after 2002, and participants were censored upon initiation of treatment for HIV or HCV. Results: There were 929 HIV/HCV co-infected and 3558 HIV mono-infected participants with a mean follow-up time of 1.2 years. HIV/HCV co-infected participants had on average a slighter lower platelet count at baseline (234,040 vs. 242,780/μL; p-value = 0.004), and a more rapid mean reduction per year (7230 vs. 3580/μL; p-value 0.001) after adjusting for age, sex, baseline CD4 count. Conclusions: In treatment naive participants, HIV/HCV co-infection is associated with a more rapid decline in platelet count compared with HIV mono-infection.
机译：背景：先前的研究表明，丙型肝炎病毒（HCV）或人免疫缺陷病毒（HIV）的感染与血小板计数低有关。这项研究估计了HIV / HCV合并感染参与者的血小板计数随时间的变化，并将其与HIV单一感染参与者中血小板计数的变化进行比较，以测试HIV / HCV合并感染是否与较低的血小板计数相关。方法：这项回顾性队列研究纳入了2002年至2009年间来自集成临床系统研究中心（CNICS）队列中四个地点的所有未接受HIV治疗的患者，并进行了血小板计数测量。我们进行了混合效应线性回归模型，对均值变化进行建模并根据年龄，性别，种族，基线CD4细胞计数和部位进行调整，从而确定每年的血小板计数。索引日期是2002年之后的第一个血小板计数，参与者在开始接受HIV或HCV治疗后受到检查。结果：共有929名HIV / HCV合并感染者和3558名HIV单一感染者，平均随访时间为1.2年。 HIV / HCV合并感染的参与者平均在基线时血小板计数较低（234,040对242,780 /μL; p值= 0.004），并且每年平均减少速度更快（7230对3580 /μL; p-调整为年龄，性别，基线CD4计数后的0.001）。结论：在未接受治疗的参与者中，与HIV单一感染相比，HIV / HCV合并感染与血小板计数更快下降有关。

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