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首页> 外文期刊>World Journal of AIDS >Quantitative Computerized Tomography (QCT) versus Dual X-Ray Absorptiometry (DXA) in the Assessment of Bone Mineral Density of HIV-1 Infected Children
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Quantitative Computerized Tomography (QCT) versus Dual X-Ray Absorptiometry (DXA) in the Assessment of Bone Mineral Density of HIV-1 Infected Children

机译：定量计算机断层扫描（QCT）与双X线骨密度仪（DXA）评估HIV-1感染儿童的骨矿物质密度

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Bone studies of HIV-infected children using dual X-ray absorptiometry (DXA) suggest bone mineral density (BMD) abnormalities. Pediatric studies are often performed using DXA instead of computed tomography (CT), which accounts for 3-dimensional differences in bone size of growing children. We evaluated whether CT would match DXA measurements in this population. For this purpose, the BMD of 16 perinatally HIV-infected patients, ages 6 to 22 was assessed. Subjects were matched by age, gender, and race to controls. BMD was assessed via DXA and QCT. Clinical anthropometric data, body mass index, immunologic and virologic parameters and laboratory markers for osteoblastic and osteoclastic activity were performed. No statistically significant differences in age and anthropometric parameters between subjects and controls were found. Individual CT and DXA z-scores were significantly different when subjects were evaluated as a group (p = 0.0002) or when males and females were analyzed independently (p = 0.001 and 0.03). DXA z-scores were below 1 SD, while CT z-scores were above the mean. 31% of subjects were identified as having poor bone mineralization by DXA while none had osteopenia/osteoporosis by CT. There was no correlation between immunologic/virologic parameters and BMD by either method. Increased osteoclastic activity was noted in 10 patients receiving tenofovir. In summary, decreased BMD diagnosed by DXA in pediatric HIV-infected subjects was not confirmed by CT. Increased bone turnover in patients on tenofovir was suggested by laboratory markers. Prospective studies using CT as the imaging standard are needed for evaluation of bone mineral changes in HIV-infected children.
机译：使用双重X射线吸收法（DXA）对受HIV感染的儿童进行的骨骼研究表明，骨矿物质密度（BMD）异常。儿科研究通常使用DXA代替计算机断层扫描（CT）进行，这可以解释成长中儿童骨骼尺寸的3维差异。我们评估了该人群中CT是否与DXA测量值相匹配。为此，对16例6至22岁的围产期HIV感染患者的BMD进行了评估。将受试者按年龄，性别和种族进行匹配。 BMD通过DXA和QCT评估。进行了临床人体测量学数据，体重指数，免疫学和病毒学参数以及成骨和破骨活动的实验室指标。在受试者和对照之间未发现年龄和人体测量学参数的统计学差异。当将受试者作为一个小组进行评估时（p = 0.0002），或者对男性和女性进行独立分析（p = 0.001和0.03）时，单独的CT和DXA z得分显着不同。 DXA z得分低于1 SD，而CT z得分高于平均值。 DXA鉴定出31％的受试者骨矿化不良，而CT则未鉴定出骨质疏松/骨质疏松症。两种方法的免疫学/病毒学参数与BMD之间均无相关性。在接受替诺福韦治疗的10名患者中发现破骨细胞活性增加。总而言之，CT并未证实DXA诊断的小儿HIV感染者的BMD降低。实验室标志物提示替诺福韦治疗患者的骨转换增加。需要使用CT作为成像标准进行前瞻性研究，以评估HIV感染儿童的骨矿物质变化。

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