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首页> 外文期刊>World Journal of AIDS >HIV Infection among Under-Five Malnourished Children in Kano State
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HIV Infection among Under-Five Malnourished Children in Kano State

机译：卡诺州五岁以下营养不良儿童中的艾滋病毒感染

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Objective: Human Immunodeficiency Viral infection and Protein Energy Malnutrition (PEM) are highly prevalent in Nigeria and when they occur together, the outcome is usually severe as both conditions lead to immune suppression. HIV alone accounts for 14.0% of childhood mortality even though children constitute only 6% of global HIV infection burden. The objective of the study was to determine the prevalence of HIV infection among malnourished children below 5 years in Kano State, Nigeria. Methods: A total of 400 malnourished children were randomly selected and tested for the presence of HIV I & II using parallel ELISA rapid test kits, Stat park and Determine (both immunochromatographic techniques). Findings: Thirty-one samples were found to be positive to HIV 1 giving a prevalence of 7.8%. There was no statistically significant difference between sexes when male to female ratio was 1:1.3 and peak age of presentation was 2 -3 years. Sixty-four percent (64.0%) were presented with severe form of HIV infection (stage 4) according to WHO paediatric HIV clinical stage and about half of them came with marasmus by the Wellcome classification of malnutrition. There was no significant association between the type of malnutrition and the severity of HIV infection at present, (p value > 0.05). The commonest signs and symptoms were oral candidiasis (67.7%), lymphadenopathy (44.0%), fever (64.5%) and cough (54.8%). Sixty-four percent of the children were from polygamous families. There was a significant statistical correlation between polygamy and incidence of HIV infection, (p 0.01). Only 45.0% of the women were aware of their HIV status prior to this study. Seventy-four percent (74.0%) of those who were aware of their status had no knowledge of the prevention of mother to child transmission (PMTCT) services and even for those who were aware, none of them accessed the care. Conclusion: A population based HIV screening is therefore recommended while perinatal HIV screening and PMTCT services need to be expanded. ?
机译：目的：人体免疫缺陷病毒感染和蛋白质能量营养不良（PEM）在尼日利亚非常普遍，当它们一起发生时，由于两种情况都会导致免疫抑制，因此结果通常很严重。即使儿童仅占全球艾滋病毒感染负担的6％，仅艾滋病毒就占儿童死亡率的14.0％。该研究的目的是确定尼日利亚卡诺州5岁以下营养不良儿童的艾滋病毒感染率。方法：随机选择400名营养不良的儿童，并使用平行ELISA快速检测试剂盒，Stat park和确定（两种免疫色谱技术）检测HIV I和II的存在。结果：发现31份样本对HIV 1呈阳性，患病率为7.8％。男女之比为1：1.3，出现高峰年龄为2 -3岁，性别之间无统计学差异。根据WHO儿科HIV临床分期，有64％（64.0％）患有严重形式的HIV感染（第4阶段），根据惠康营养不良分类，其中约有一半患有黑斑病。目前，营养不良的类型与HIV感染的严重程度之间没有显着关联（p值> 0.05）。最常见的体征和症状是口腔念珠菌病（67.7％），淋巴结病（44.0％），发烧（64.5％）和咳嗽（54.8％）。百分之六十四的孩子来自一夫多妻制家庭。一夫多妻制与HIV感染发生率之间存在显着的统计学相关性（p = 0.01）。在这项研究之前，只有45.0％的妇女知道自己的艾滋病毒状况。知道自己状况的人中有74％（74.0％）不知道如何预防母婴传播（PMTCT）服务，即使对于那些知道这一点的人，他们也没有人获得这种护理。结论：因此，建议进行基于人群的HIV筛查，同时需要扩大围产期HIV筛查和PMTCT服务。 ？

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