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首页> 外文期刊>World Journal of AIDS >Characterization of Candida Species Isolated from Cases of Lower Respiratory Tract Infection among HIV/AIDS Patients in Calabar, Nigeria
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Characterization of Candida Species Isolated from Cases of Lower Respiratory Tract Infection among HIV/AIDS Patients in Calabar, Nigeria

机译：尼日利亚卡拉巴尔艾滋病毒/艾滋病患者下呼吸道感染病例中分离出的念珠菌的特征

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This study was designed to identify and characterize the Candida species isolated from lower respiratory tract infections among HIV positive patients and to determine the prevalence rates of Candida infections among these subjects. Two early morning expectorate sputum samples were collected from 272 HIV positive subjects visiting the ART clinics and DOTS centre with cases of lower respiratory tract infection, over a period of 14 months from May 2009 to July 2010 in Calabar. Subjects were recruited for this study upon approval by the Ethical Research Committee of the University of Calabar Teaching Hospital and obtaining written informed consent from the patients. Samples were processed by standard methods for isolation of Candida. Speciation was done by a germ tube test, chlamydospore production on corn meal agar and sugar fermentation and assimilation tests using the Microexpress Candida identification kit (Tulip, India). Out of the 544 sputum samples collected from 272 subjects, Candida species were isolated from 40 (14.7%) and identified after confirming the growth in the second sample. The majority of Candida species among the Candida isolates were Candida albicans (80%) followed by Candida tropicalis 5 (12.5%), Candida dubliniensis 2 (5.0%) and Candida guilliermondii 1 (2.5%). The isolation rate of Candida species from sputum samples was found to be highest among subjects aged 25 - 34 years, followed by those aged 15 - 24 years. Twenty (7.3%) HIV seropositive subjects had bacterial infections, while 4 (1.5%) subjects had mixed fungal and bacterial infections. This study is the first of its kind to be carried out in Calabar and the South-South geopolitical region of Nigeria, and has shown that pulmonary candidiasis is a health problem among HIV positive patients in Calabar.
机译：本研究旨在鉴定和鉴定从HIV阳性患者中从下呼吸道感染中分离出来的念珠菌种类，并确定这些受试者中念珠菌感染的患病率。从2009年5月至2010年7月，在14个月的时间里，从272名HIV阳性受试者中抽取了两个清晨痰标本，这些受试者前往ART诊所和DOTS中心进行下呼吸道感染病例。经卡拉巴大学教学医院大学伦理研究委员会批准，并征得患者的书面知情同意后，招募了受试者进行这项研究。通过标准方法处理样品以分离假丝酵母。通过使用Microexpress Candida鉴定试剂盒（印度郁金香）的胚芽管试验，玉米粉琼脂上的衣原体孢子生产和糖发酵以及同化试验来进行形态鉴定。从272名受试者收集的544份痰样本中，从40份（14.7％）中分离出念珠菌，并在确认第二份样本的生长后对其进行了鉴定。在念珠菌分离物中，大多数念珠菌物种为白色念珠菌（80％），其次是热带念珠菌5种（12.5％），杜比利尼假丝酵母2种（5.0％）和古德里假丝酵母1种（2.5％）。从痰液样本中分离出念珠菌的比率在25-34岁的受试者中最高，其次是15-24岁的受试者。 20位（7.3％）HIV血清阳性患者感染了细菌，而4位（1.5％）感染了真菌和细菌。这项研究是在尼日利亚的卡拉巴尔和南南地缘政治地区进行的首项此类研究，表明肺念珠菌病是卡拉巴尔艾滋病毒阳性患者中的健康问题。

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