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首页> 外文期刊>World Journal of Surgical Oncology >Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC
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Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC

机译:腹膜内丝裂霉素C引起的肺毒性:HIPEC罕见并发症的一例报道

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Background Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become a common treatment approach for disseminated appendiceal neoplasms. Systemic absorption of intraperitoneal chemotherapeutics may lead to drug-induced toxicity, most commonly neutropenia. Mitomycin C has been the most commonly used chemotherapeutic in HIPEC for the past several decades. Case presentation Here, we describe a rare pulmonary complication secondary to intraperitoneal administration of mitomycin C. Conclusions While rare, intraperitoneal mitomycin C has the potential to cause serious pulmonary toxicity that should be considered with administration. To our knowledge, this report represents only the second case described in the literature.
机译:背景细胞减灭术联合腹膜内高温化疗(CRS / HIPEC)已成为弥漫性阑尾肿瘤的常见治疗方法。腹膜内化疗药物的全身吸收可能导致药物引起的毒性反应,最常见的是中性粒细胞减少症。在过去的几十年中,丝裂霉素C一直是HIPEC中最常用的化学疗法。病例介绍在这里,我们描述了一种在丝裂霉素C腹膜内给药后继发的罕见肺部并发症。结论虽然很少见,腹膜内丝裂霉素C可能引起严重的肺毒性,应考虑给药。就我们所知,该报告仅代表文献中描述的第二种情况。

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