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首页> 外文期刊>World Journal of Vaccines >Immunostimulatory Effect of Levamisole on the Immune Response of Goats to Peste des petits ruminants (PPR) Vaccination
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Immunostimulatory Effect of Levamisole on the Immune Response of Goats to Peste des petits ruminants (PPR) Vaccination

机译：左旋咪唑对山羊对小反刍兽疫（PPR）疫苗免疫反应的免疫刺激作用。

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The use of Levamisole hydrochloride as an immunostimulant has been successful in the control of certain diseases such as Derzsy’s disease in chicken as well as in increasing lymphocytes and weight gain in pigs. However, its use as immunostimulant in the prevention of Peste des petits ruminants (PPR) in goats has not been investigated. In this study, the use of Levamisole in enhancing immune response to PPR vaccination including its effects on weight gain was investigated among groups of goats (groups A, B, C and D). Virus neutralization test was used to determine the antibody profile in vaccinated goats while the total and differential leucocyte counts and body mass index (BMI) were determined using standard procedures. Goats in group A (Levamisole primed and PPR vaccinated) seroconverted to more than 3-folds of the initial pre-vaccination geometric mean titre (GMT) of neutralizing antibody beginning from second week post-vaccination and remained high throughout the period of the experiment. Similarly, there was significant increase (p 0.05) in BMI of animals in other groups throughout the period of the experiment. The results of this study further confirm the immunostimulatory effect of Levamisole when used in combination with a vaccine.
机译：使用盐酸左旋咪唑作为免疫刺激剂已成功地控制了某些疾病，例如鸡的Derzsy病以及猪的淋巴细胞增加和体重增加。但是，尚未研究将其用作预防山羊反刍动物反刍动物（PPR）的免疫刺激剂。在这项研究中，在山羊组（A，B，C和D组）中研究了左旋咪唑在增强对PPR疫苗免疫反应中的用途，包括其对体重增加的影响。使用病毒中和试验确定接种山羊的抗体谱，同时使用标准程序确定总白细胞计数和差异白细胞计数以及体重指数（BMI）。从疫苗接种后第二周开始，A组中的山羊（Levamisole初免和PPR疫苗接种）血清转化为中和抗体初始接种前几何平均滴度（GMT）的3倍以上，并在整个实验过程中保持较高水平。同样，在整个实验过程中，其他组动物的BMI也有显着增加（p 0.05）。这项研究的结果进一步证实了左旋咪唑与疫苗联合使用时的免疫刺激作用。

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