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首页> 外文期刊>World Journal of Preventive Medicine >The Markers of Systemic Inflammation in Patients with Chronic Periodontitis: Leukocytes, C-reactive Protein and Fibrinogen
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The Markers of Systemic Inflammation in Patients with Chronic Periodontitis: Leukocytes, C-reactive Protein and Fibrinogen

机译：慢性牙周炎患者全身炎症的标志物：白细胞，C反应蛋白和纤维蛋白原

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Background: Periodontitis has been identified as potential risk factors for systemic pathologies. The aim of this study was to investigate the relationship between periodontitis and systemic inflammatory markers, as well as, if there is a relation to severity of periodontitis. Methodology: Periodontal examinations and serum markers of inflammation levels mesaurements were performed in 50 patients. The patients with moderate periodontitis had low CAL and PD < 5mm. The patients with severe periodontitis were with high CAL and PD > 5mm. The clinical parameters of periodontitis were determined among all subjects. The LEU, CRP, and FIB for the present investigation were obtained from peripheral venous blood patients from all groups. Findings: In both moderate and severe periodontitis, the results indicated that the total leukocytes count and neutrophils had a significantly higher count (p < 0.001) among the groups with periodontitis but that there was no significance in the lymphocytes counts. The results also show a significant relation between indicators of poor periodontal status and increased levels CRP and fibrinogen. Conclusion: Periodontitis is associated with an enhanced inflammatory response expressed by higher levels of inflammatory markers. The extent of increase in these marker levels in periodontitis patients depends of severity of the disease. Significance: The association of periodontitis with WBC, CRP and fibrinogen levels appears to be contributing factors for CVD and might be a possible intermediate pathway in this association.
机译：背景：牙周炎已被确定为系统性病理的潜在危险因素。这项研究的目的是调查牙周炎和全身炎症标志物之间的关系，以及是否与牙周炎的严重程度有关。方法：对50例患者进行了牙周检查和血清标志物炎症水平的测定。中度牙周炎患者的CAL和PD <5mm低。重度牙周炎患者的CAL和PD> 5mm。在所有受试者中确定牙周炎的临床参数。本研究的LEU，CRP和FIB从各组的外周静脉血患者中获得。结果：在中度和重度牙周炎中，结果表明，在牙周炎组中，白细胞总数和中性粒细胞总数显着更高（p <0.001），但淋巴细胞计数没有意义。结果还表明，牙周状况不佳的指标与CRP和纤维蛋白原水平升高之间存在显着相关性。结论：牙周炎与较高水平的炎症标记物表达的炎症反应增强有关。这些标志物水平在牙周炎患者中增加的程度取决于疾病的严重程度。意义：牙周炎与WBC，CRP和纤维蛋白原水平的关联似乎是CVD的促成因素，并且可能是这种关联的可能的中间途径。

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