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首页> 外文期刊>Yonsei Medical Journal >Therapeutic time window for methylprednisolone in spinal cord injured rat
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Therapeutic time window for methylprednisolone in spinal cord injured rat

机译：甲基强的松龙在脊髓损伤大鼠中的治疗时间窗

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摘要

Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly even deleterious when given more than 8 hours after injury. This finding suggests that a therapeutic time window exists in spinal cord injury. In order to determine the doses, durations and timing of methylprednisolone treatment for optimal neuroprotection, a single or two bolus dose of methylprednisolone (30 mg/kg) was administered at 10, 30, 120, 150 and 240 min. after three graded spinal cord injury. The primary outcome measure was 24-hour spinal cord lesion volumes estimated from spinal cord Na+ and K+ shifts. A single 30 mg/kg dose of methylprednisolone at 10 min. after injury significantly reduced 24-hour lesion volumes in injured rat spinal cords. However, any other methylprednisolone treatment starting 30 min. or more after injury had no effect on 24-hour lesion volumes compared to the vehicle control group. Moreover, delayed treatment increased lesion volumes in some cases. These results suggest that the NYU SCI model has a very short therapeutic window.
机译：最近的临床试验报道，甲基强的松龙琥珀酸钠在8小时内给药可改善人脊髓损伤（SCI）的神经功能。然而，甲基强的松龙在受伤后超过8小时服用无效，甚至可能有害。该发现表明在脊髓损伤中存在治疗时间窗。为了确定用于最佳神经保护的甲基强的松龙的剂量，持续时间和时机，在10、30、120、150和240分钟分别给予单次或两次大剂量的甲基强的松龙（30 mg / kg）。三级脊髓损伤后。主要结局指标是根据脊髓Na + 和K + 位移估计的24小时脊髓病变量。在10分钟时单次服用30 mg / kg甲基强的松龙。损伤后，大鼠脊髓损伤后的24小时病变体积明显减少。但是，任何其他甲基强的松龙治疗都应在30分钟后开始。与车辆对照组相比，受伤后24小时或以上对24小时病变体积无影响。此外，延迟治疗在某些情况下增加了病变体积。这些结果表明，NYU SCI模型的治疗窗口非常短。

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