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首页> 外文期刊>The European Journal of Neuroscience >The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats.
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The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats.

机译：脊髓损伤后的治疗窗可适应大鼠T细胞疫苗和甲基强的松龙。

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Abstract Immune system activity has traditionally been considered harmful for recovery after spinal cord injury (SCI). Recent evidence suggests, however, that immune activity - and specifically autoimmune activity - is evoked by the insult, is beneficial if properly regulated and is amenable to boosting. Thus, for example, vaccination with an altered peptide ligand derived from myelin basic protein reduces the progressive degeneration of neurons that escaped the initial insult, thereby promoting recovery after SCI. As the steroid drug methylprednisolone (MP) is currently the only treatment available for patients with SCI, our purpose in the present study was to examine the mutual compatibility of the two treatments within the post-traumatic therapeutic window. We show, using rats of two different strains, that if MP is injected concomitantly with the therapeutic vaccination, the beneficial effect of the vaccination is diminished. However, if MP is given immediately after the insult and the vaccination 48 h later, MP does not detract from the beneficial effect of the vaccination. These results demonstrate that the therapeutic window after SCI can accommodate immediate administration of MP plus a delayed therapeutic vaccination.
机译：摘要传统上认为免疫系统活动对脊髓损伤（SCI）后的恢复有害。但是，最近的证据表明，这种损害会引起免疫活性，特别是自身免疫活性，如果得到适当的调节并有益于增强免疫力，那将是有益的。因此，例如，用衍生自髓鞘碱性蛋白的改变的肽配体进行疫苗接种减少了逃脱初始损伤的神经元的进行性退化，从而促进了SCI后的恢复。由于类固醇药物甲基泼尼松龙（MP）是目前唯一可用于SCI患者的治疗方法，因此我们在本研究中的目的是在创伤后治疗窗口内检查两种治疗方法的相互相容性。我们显示，使用两种不同品系的大鼠，如果将MP与治疗性疫苗同时注射，则疫苗的有益作用会降低。但是，如果在感染后立即注射MP，并在48小时后接种疫苗，MP不会减损疫苗的有益作用。这些结果表明，SCI后的治疗窗口可适应MP的即时给药以及延迟的治疗疫苗接种。

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