Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

Liviu Feller; Neil H Wood; Razia AG Khammissa; Johan Lemmer

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Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第1部分：人乳头瘤病毒介导的致癌作用

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High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

机译：高危型人乳头瘤病毒（HPV）E6和E7癌蛋白是HPV诱导的癌变以及维持随后的肿瘤生长的必要因素。这些癌基因与细胞周期调控的几种细胞因子（包括p53，Rb，cyclin-CDK复合物，p21和p27）的复杂相互作用，可实现细胞转化。高危HPV基因型的持续感染和免疫失调均与HPV诱导的鳞状细胞癌的风险增加有关。

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《Head Face Medicine》 |2010年第3期|共页
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Liviu Feller; Neil H Wood; Razia AG Khammissa; Johan Lemmer;
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中图分类整形外科学（修复外科学）;
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1. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma [J] . Liviu Feller, Neil H Wood, Razia AG Khammissa, Head Face Medicine . 2010,第3期

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第2部分：人乳头瘤病毒相关的口腔和口咽鳞状细胞癌
2. African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated carcinogenesis [J] . IsayevaT., XuJ., DaiQ., Human Pathology . 2014,第2期

机译：尽管人类乳头瘤病毒介导的癌变发生率相近，但患有口咽癌的非裔美国人的结局明显较差
3. Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis [J] . Chuqing Zhang, Yunjing Luo, Rugang Zhong, BMC Cancer . 2019,第1期

机译：多环芳烃作为人乳头瘤病毒介导的致癌作用的作用
4. Modified Binary Dragonfly Algorithm for Feature Selection in Human Papillomavirus-Mediated Disease Treatment [C] . Ramit Sawhney, Roopal Jain 2018 International Conference on Communication, Computing and Internet of Things . 2018

机译：改进的二进制蜻蜓算法在人乳头瘤病毒介导的疾病治疗中的特征选择
5. The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma. [D] . Anand, Sumeet M. 2009

机译：口腔和口咽鳞状细胞癌的肿瘤体积与生存率的关系。
6. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis [O] . Liviu Feller, Neil H Wood, Razia AG Khammissa, 2010

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第1部分：人乳头瘤病毒介导的癌变
7. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis [O] . Khammissa Razia AG, Wood Neil H, Feller Liviu, 2010

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第1部分：人乳头瘤病毒介导的癌变

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

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