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首页> 外文期刊>Yonsei Medical Journal >Plasma Total Homocysteine Level Is Associated with the Pulsatility Index of Cerebral Arteries in Lacunar Infarction
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Plasma Total Homocysteine Level Is Associated with the Pulsatility Index of Cerebral Arteries in Lacunar Infarction

机译：血浆总同型半胱氨酸水平与腔隙性脑梗死脑动脉的搏动指数相关

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Purpose The pulsatility index (PI), measured by transcranial Doppler (TCD), is a surrogate marker for distal vascular resistance in cerebral arteries, and elevated plasma total homocysteine (tHcyt) is regarded as a cause of ischemic stroke, including lacunar infarction. We investigated the relationship between the PI of cerebral arteries and plasma tHcyt in patients with lacunar infarction. Materials and Methods Plasma tHcyt level and TCD examination were performed in 94 patients with lacunar infarction. Mean flow velocity (MFV) and PI were assessed at the ipsilateral middle cerebral artery (MCA) and contralateral MCA, relative to the infarction, and the basilar artery (BA). Multivariate regression analysis was conducted between log-transformed tHcyt levels (logHcyt) and the PI of individual arteries. Results There was a significant correlation between logHcyt and the PI in all tested arteries (ipsilateral MCA: r=0.21, p =0.03; contralateral MCA: r=0.21, p =0.04; BA: r=0.35, p =0.01). In multivariate regression analysis, this significance remained unchanged after adjusting for vascular risk factors, creatinine, hematocrit and platelet count (ipsilateral MCA: β=0.26, p =0.01; contralateral MCA: β=0.21, p =0.04; BA: β=0.39, p =0.001). There was no significant association between logHcyt and MFV of individual arteries. Conclusion A significant association between plasma tHcyt and the PI of cerebral arteries indicates that homocysteine plays a role in the increase of distal arterial resistance in lacunar infarction.
机译：目的经颅多普勒（TCD）测量的搏动指数（PI）是脑动脉远端血管阻力的替代指标，血浆总同型半胱氨酸（tHcyt）升高被认为是缺血性中风的原因，包括腔隙性脑梗塞。我们调查了腔隙性脑梗死患者脑动脉PI与血浆tHcyt之间的关系。材料与方法对94例腔隙性脑梗死患者进行血浆tHcyt水平和TCD检查。在同侧大脑中动脉（MCA）和对侧MCA（相对于梗死）和基底动脉（BA）处评估平均流速（MFV）和PI。在对数转换的tHcyt水平（logHcyt）和单个动脉的PI之间进行了多元回归分析。结果在所有受测动脉中，logHcyt与PI之间存在显着相关性（同侧MCA：r = 0.21，p = 0.03;对侧MCA：r = 0.21，p = 0.04; BA：r = 0.35，p = 0.01）。在多变量回归分析中，在调整了血管危险因素，肌酐，血细胞比容和血小板计数后，该显着性保持不变（同侧MCA：β= 0.26，p = 0.01;对侧MCA：β= 0.21，p = 0.04; BA：β= 0.39 ，p ＝ 0.001）。 logHcyt与单个动脉的MFV之间无显着关联。结论血浆tHcyt与脑动脉PI之间存在显着相关性，表明同型半胱氨酸在腔隙性脑梗死的远端动脉阻力增加中起一定作用。

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