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首页> 外文期刊>Herba Polonica >Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility
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Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility

机译：太子参提取物水溶液的溶解度和增溶能力。根据Hildebrand-Scatchard-Fedors一般溶解度理论的选定值进行干燥

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Introduction: The general Hildebrand-Scatchard theory of solubility supplemented by Fedors’ solubility parameter ? δ 1 2 was used to estimate the real solubility by ?log x2 (log of the mole fraction) of phytochemicals contained in Ext. Taraxaci e radix cum herba aqu. siccum . Surface activity of aqueous solution of extracts was determined and quantified – solubilizing capabilities of solutions of cexp. ≥cmc in relation to cholesterol particle size of ?=1.00 mm, as well as of ketoprofen were defined. Objective: The calculated value ?log x2 collated with the polarity of extraction medium εM allows to estimate the optimal solubility of phytochemicals that determine the viscosity of the aqueous extract of dandelion and above all its surface activity and the ability to solubilize lipophilic therapeutic agents (ketoprofen). Methods: Viscosity of water model solutions of dandelion extracts and exhibition solutions after the effective micellar solubilization of cholesterol and ketoprofen was measured using Ubbelohde viscometer in accordance with the Polish Standard. The surface tension of aqueous solutions of extract and exhibition solutions after solubilization of cholesterol and ketoprofen was measured according to the Polish Standard with stalagmometric method. Results: The calculated factual solubility, and mainly the determined and calculated hydrodynamic size mean, that despite the complex structure of the micelle, it solubilizes cholesterol (granulometric grain of diameter ?=1.00 mm) and ketoprofen (state of technological fragmentation) in equilibrium conditions. Equilibrium solubilization of ketoprofen also occurs in an environment of model gastric juice (0.1 mol HCl). Conclusions: The obtained results indicate that after the administration (and/or dietary supplementation) with Ext. Taraxaci e radix cum herba aqu. siccum , the physiological parameters of gastric juice would not be measured and its presence (phytosurfactant) in the body of the duodenum (bile A) increases abilities of solubilizing lipophilic therapeutic agents and cholesterol accounting for its use in the treatment of liver diseases and cholesterol gall bladder stones.
机译：简介：一般的Hildebrand-Scatchard溶解度理论辅以Fedors的溶解度参数？ δ1 2用于通过Ext中包含的植物化学物质的？log x 2 （摩尔分数的对数）估算实际溶解度。蒲公英和草本植物。干燥测定并定量提取液的表面活性-定义c ≥cmc的溶液相对于胆固醇= 1.00 mm的胆固醇大小的溶解能力，以及酮洛芬的溶解能力。目的：计算值？log x 2 与提取介质ε M 的极性核对，可以估算确定蒲公英水提物粘度的植物化学物质的最佳溶解度。尤其是其表面活性和增溶亲脂性治疗剂（酮洛芬）的能力。方法：根据波兰标准，使用Ubbelohde粘度计测量蒲公英胶和酮洛芬有效胶束溶解后的蒲公英提取物和展示液的水模型溶液的粘度。胆固醇和酮洛芬溶解后，提取物和展露溶液的水溶液的表面张力根据波兰标准用石笋法测定。结果：计算出的实际溶解度，主要是确定和计算出的流体力学尺寸平均值，尽管胶束结构复杂，但在平衡条件下仍能溶解胆固醇（粒径为1.00 mm的粒度颗粒）和酮洛芬（技术裂解状态） 。酮洛芬的平衡溶解也发生在模型胃液（0.1 mol HCl）的环境中。结论：获得的结果表明在给予（和/或饮食补充）Ext后。蒲公英和草本植物。干燥，无法测量胃液的生理参数，十二指肠内（胆汁A）中胃液的存在（植物表面活性剂）增加了脂溶性治疗剂和胆固醇的溶解能力，这归因于其在治疗肝脏疾病和胆固醇gall中的用途膀胱结石。

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