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首页> 外文期刊>Hong Kong Journal of Paediatrics >Growth of Children with Urolithiasis Associated with Melamine-contaminated Milk Powder: A Follow-up Study
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Growth of Children with Urolithiasis Associated with Melamine-contaminated Milk Powder: A Follow-up Study

机译：与三聚氰胺污染的奶粉相关的尿石症儿童的生长：一项后续研究

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Objective: To study the impact of melamine-contaminated milk powder on children's growth and development and the elimination of urinary tract stones. Patients and Methods: Seventy-three patients aged ≤4 years with ultrasonographically diagnosed urolithiasis after intake of contaminated milk powder were compared with 79 healthy controls. Assessment included indicators of growth and development based on reference data from World Health Organisation (WHO) standards, Brightness mode (B-mode) ultrasonography as well as urine and blood lab analysis. Results: According to WHO standards, whether at time of diagnosis or 18 months after follow-up, urolithiasis patients all showed generally lower z-scores, compared with control. At time of diagnosis, the differences were statistically significant for weight-for-age, weight-for-length and head circumference in children age ≤2 years and for weight-for-age, length/height-for-age and head circumference in the age groups 2 to 3 years and 3 to 4 years (all p<0.05). Eighteen months after follow-up, urolithiasis patient, had significant smaller values for length-for-age in children age ≤2 years and for weight-for-age, length/height-for-age and head circumference in the age groups 2 to 3 years and 3 to 4 years (all p<0.05). While the patient group and the control showed no statistically difference between diagnosis and 18 months follow-up. On follow-up B-mode ultrasonography 18 months after the diagnosis, five (6.85%) children still showed intrarenal calculi, one (1.37%) child suffered from hydronephrosis. Serum levels of alanine aminotransferase, creatinine and uric acid were within normal range. Proteinuria was not observed. Conclusions: Consumption of melamine-contaminated milk power affects growth and development. Melamine-associated urolithiasis can persist for longer periods of time after cessation of melamine intake. A significant long-term effect of contaminated milk powder on liver and kidney function was not observed.
机译：目的：研究被三聚氰胺污染的奶粉对儿童生长发育和消除尿路结石的影响。患者与方法：将73例≤4岁，摄入受污染的奶粉后经超声检查诊断为尿路结石的患者与79名健康对照者进行比较。评估包括根据世界卫生组织（WHO）标准的参考数据，Brightness模式（B模式）超声检查以及尿液和血液实验室分析得出的生长和发育指标。结果：根据WHO的标准，无论是在诊断时还是在随访18个月后，尿路结石病患者的z得分均比对照组低。诊断时，≤2岁儿童的年龄体重，身长体重和头围的统计学差异显着，而年龄≤2岁的儿童体重年龄，身长/身高和头围的差异具有统计学意义。 2至3岁年龄组和3至4岁年龄组（均p <0.05）。随访18个月，尿路结石病患者的≤2岁儿童的年龄长度和2至12岁年龄组的体重，年龄/身高/头围和头围的值均显着较小。 3年和3至4年（所有p <0.05）。虽然患者组和对照组在诊断与18个月随访之间无统计学差异。在诊断后18个月进行的B型超声检查中，仍有5名（6.85％）儿童出现肾内结石，其中1名（1.37％）儿童患有肾积水。血清丙氨酸转氨酶，肌酐和尿酸水平在正常范围内。未观察到蛋白尿。结论：受三聚氰胺污染的牛奶粉的消耗会影响生长发育。三聚氰胺相关的尿路结石症可在三聚氰胺摄入停止后持续较长时间。没有观察到受污染的奶粉对肝脏和肾脏功能的长期影响。

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