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首页> 外文期刊>Hong Kong Journal of Paediatrics >Prognostic Factors and Outcome of Wilms' Tumour in a Tertiary Children's Hospital, China
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Prognostic Factors and Outcome of Wilms' Tumour in a Tertiary Children's Hospital, China

机译：三级儿童医院Wilms肿瘤的预后因素和结果

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摘要

Wilms' tumour is the most frequent malignant neoplasm of the kidney in children. Multimodal treatment was used in treating this tumour, and it has achieved the best results for any tumour group. We studied all the patients who underwent surgery for unilateral Wilms' tumour at Children's Hospital, Zhejiang University School of Medicine during the 15-year period from January 1992 through December 2006. A total of 92 patients were treated for the unilateral Wilms' tumour during the study period, among whom 11 patients were excluded out of this analysis due to the loss of first follow-up after discharge from the hospital. The overall survival of the 81 patients was 76.6%. Cox analysis revealed that anaplastic histology, stage III and without preoperative treatment are risk factors for Wilms' tumour. Pre-operative treatment plays an important role in the treatment of Wilms' tumour and it will lead to better outcome for the patients. Treatment for Wilms' tumour with anaplastic histology and tumour recurrence remains a big challenge in China. The overall survival is still lower than that in developed countries and multi-modality treatment should be optimised for Wilms' tumour patients in China.
机译：肾母细胞瘤是儿童肾脏中最常见的恶性肿瘤。多模式治疗被用于治疗该肿瘤，并且对于任何肿瘤组都取得了最佳效果。我们研究了1992年1月至2006年12月这15年间在浙江大学医学院附属儿童医院接受单侧Wilms肿瘤手术的所有患者。在治疗期间，共92例接受了单侧Wilms肿瘤治疗的患者。研究期间，由于出院后失去首次随访，其中有11名患者被排除在本分析之外。 81例患者的总生存率为76.6％。 Cox分析显示，间变性组织学（III期）且未经术前治疗是威尔姆斯肿瘤的危险因素。术前治疗在治疗维尔姆斯肿瘤中起着重要的作用，它将为患者带来更好的结果。变性组织学和肿瘤复发治疗Wilms肿瘤在中国仍然是一个巨大的挑战。总体生存率仍低于发达国家，应针对中国的威尔姆斯肿瘤患者优化多模式治疗。

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