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Lipomatous angiomyofibroblastoma: A 20-year literature review

机译：脂肪瘤性血管肌纤维母细胞瘤：20年文献回顾

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摘要

Lipomatous angiomyofibroblastoma (LAMF) is a rare superficial muco-cutaneous tumor of the female genital tract in women of reproductive age and early menopause. We report the case of a 36-year-old woman who presented with an asymptomatic 1 cm round vulvar mass. The tumor showed both hypercellular and hypocellular areas composed of spindle and epithelioid cells set in a loose fibromyxoid background. Anastomosing networks of small to medium sized dilated vessels, surrounded by condensed spindle cells, were distributed equally throughout the tumor. Mature adipocytes comprised more than half of the tumor's volume. The neoplastic cells were reactive for both desmin and vimentin and did not express CD34, smooth muscle actin, S100 protein and muscle-specific actin. Making the right diagnosis may be challenging to medical professionals as LAMF may mimic both clinically and histologically several other benign and malignant gynecological lesions. LAMF has a benign course without evidence of local recurrence or metastatic potential.
机译：脂肪瘤性血管肌纤维母细胞瘤（LAMF）是育龄期和更年期早期妇女中女性生殖道的一种罕见的浅表皮肤粘膜皮肤肿瘤。我们报告了一名无症状的1厘米圆形外阴肿块的36岁妇女的病例。肿瘤显示出由纺锤体和上皮样细胞组成的高细胞区和低细胞区，其位于松散的纤维粘胶蛋白背景中。小到中型扩张血管的吻合网络被浓缩的梭形细胞包围，在整个肿瘤中平均分布。成熟的脂肪细胞占肿瘤体积的一半以上。肿瘤细胞对结蛋白和波形蛋白均具有反应性，不表达CD34，平滑肌肌动蛋白，S100蛋白和肌肉特异性肌动蛋白。由于LAMF可能在临床和组织学上模仿其他几种良性和恶性妇科病变，因此对医学专业人员进行正确的诊断可能具有挑战性。 LAMF具有良性病程，没有局部复发或转移潜力的证据。

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