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Variation in the Ace Gene in Elite Polish Football Players

机译：波兰优秀足球运动员Ace基因的变异

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Purpose. A common polymorphism in the angiotensin converting enzyme I gene (the ACE I/D variant) represents one of the first characterized and the most widely studied genetic variants in the context of elite athletes status and performance related traits. The aim of the study was to determine the genotype and allele distribution of the allele and genotype of the ACE gene in Polish male football players. Methods. The total of 106 Polish male professional football players were recruited. They were divided into groups according to the position in the field: forwards, defenders, midfielders, and goalkeepers. For controls, samples were prepared with 115 unrelated volunteers. DNA was extracted from the buccal cells donated by the subjects, and the PCR amplification of the polymorphic region of the ACE gene containing either the insertion (I) or deletion (D) fragment was performed. Results. The genotype distribution and allele frequencies among all football players did not differ significantly when compared with sedentary control individuals (p = 0.887, p = 0.999, respectively). Likewise, the analysis of forwards, defenders, midfielders, and goalkeepers revealed no significant differences in either ACE genotype or allele frequencies. Conclusions. We did not provide evidence for difference of variation of the ACE I/D polymorphism between Polish football players and controls, as we did not obtain any statistically significantly higher frequency of either of the analysed alleles (I and D) or genotypes (DD, ID, and II) in the studied subgroups. It may be suspected that harbouring of I/D allelic variants of the ACE gene neither decreases nor increases the probability of being a professional football player in Poland.
机译：目的。血管紧张素转化酶I基因（ACE I / D变体）中常见的多态性代表了精英运动员的状态和与表现相关的特征中最早被表征且研究最广泛的遗传变体之一。这项研究的目的是确定波兰男足球运动员的ACE基因的基因型和等位基因分布以及ACE基因的基因型。方法。总共征聘了106名波兰男性职业足球运动员。根据领域的位置将他们分为几类：前锋，后卫，中场和守门员。作为对照，样品与115名无关的志愿者一起准备。从受试者捐赠的颊细胞中提取DNA，并对包含插入（I）或缺失（D）片段的ACE基因的多态性区域进行PCR扩增。结果。与久坐的对照组相比，所有足球运动员之间的基因型分布和等位基因频率均无显着差异（分别为p = 0.887，p = 0.999）。同样，对前锋，后卫，中场和守门员的分析表明，ACE基因型或等位基因频率均无显着差异。结论。我们没有提供波兰足球运动员和对照组之间ACE I / D多态性差异差异的证据，因为我们没有获得分析等位基因（I和D）或基因型（DD，ID）的任何统计学上显着更高的频率和II）。怀疑ACE基因的I / D等位基因变体的存在既不会减少也不会增加在波兰成为职业足球运动员的可能性。

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