...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Database >CCSI: a database providing chromatin–chromatin spatial interaction information
【24h】

CCSI: a database providing chromatin–chromatin spatial interaction information

机译：CCSI：提供染色质-染色质空间相互作用信息的数据库

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Distal regulatory elements have been shown to regulate gene transcription through spatial interactions, and single nucleotide polymorphisms (SNPs) are linked with distal gene expression by spatial proximity, which helps to explain the causal role of disease-associated SNPs in non-coding region. Therefore, studies on spatial interactions between chromatin have created a new avenue for elucidating the mechanism of transcriptional regulation in disease pathogenesis. Recently, a growing number of chromatin interactions have been revealed by means of 3C, 4C, 5C, ChIA-PET and Hi-C technologies. To interpret and utilize these interactions, we constructed chromatin–chromatin spatial interaction (CCSI) database by integrating and annotating 91 sets of chromatin interaction data derived from published literature, UCSC database and NCBI GEO database, resulting in a total of 3 017 962 pairwise interactions (false discovery rate??0.05), covering human, mouse and yeast. A web interface has been designed to provide access to the chromatin interactions. The main features of CCSI are (i) showing chromatin interactions and corresponding genes, enhancers and SNPs within the regions in the search page; (ii) offering complete interaction datasets, enhancer and SNP information in the download page; and (iii) providing analysis pipeline for the annotation of interaction data. In conclusion, CCSI will facilitate exploring transcriptional regulatory mechanism in disease pathogenesis associated with spatial interactions among genes, regulatory regions and SNPs. Database URL: http://songyanglab.sysu.edu.cn/ccsi
机译：已显示远距离调控元件通过空间相互作用调控基因转录，并​​且单核苷酸多态性（SNP）通过空间邻近性与远端基因表达相关，这有助于解释与疾病相关的SNP在非编码区的因果作用。因此，关于染色质之间空间相互作用的研究为阐明疾病发病机理中转录调控的机制开辟了一条新途径。最近，通过3C，4C，5C，ChIA-PET和Hi-C技术揭示了越来越多的染色质相互作用。为了解释和利用这些相互作用，我们通过整合和注释来自公开文献，UCSC数据库和NCBI GEO数据库的91组染色质相互作用数据，构建了染色质-染色质空间相互作用（CCSI）数据库，总共产生了3017962个成对相互作用（错误发现率≤0.05），涵盖人，小鼠和酵母菌。已设计一个Web界面以提供对染色质相互作用的访问。 CCSI的主要特征是：（i）在搜索页面区域内显示染色质相互作用和相应的基因，增强子和SNP。 （ii）在下载页面中提供完整的交互数据集，增强子和SNP信息; （iii）提供用于注释交互数据的分析管道。总之，CCSI将促进探索疾病发病机制中与基因，调控区域和SNP之间空间相互作用相关的转录调控机制。数据库URL：http://songyanglab.sysu.edu.cn/ccsi

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号