CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease

Jihong Yang; Leihong Wu; Xiang Li; Xiaohui Fan; Yiyu Cheng; Yufeng Liu

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CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease

机译：CHD @ ZJU：一个知识库，提供基于网络的冠心病研究平台

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Coronary heart disease (CHD), the leading cause of global morbidity and mortality in adults, has been reported to be associated with hundreds of genes. A comprehensive understanding of the CHD-related genes and their corresponding interactions is essential to advance the translational research on CHD. Accordingly, we construct this knowledgebase, CHD@ZJU, which records CHD-related information (genes, pathways, drugs and references) collected from different resources and through text-mining method followed by manual confirmation. In current release, CHD@ZJU contains 660 CHD-related genes, 45 common pathways and 1405 drugs accompanied with 8000 supporting references. Almost half of the genes collected in CHD@ZJU were novel to other publicly available CHD databases. Additionally, CHD@ZJU incorporated the protein–protein interactions to investigate the cross-talk within the pathways from a multi-layer network view. These functions offered by CHD@ZJU would allow researchers to dissect the molecular mechanism of CHD in a systematic manner and therefore facilitate the research on CHD-related multi-target therapeutic discovery. Database URL: http://tcm.zju.edu.cn/chd/

机译：冠心病（CHD）是成年人全球发病率和死亡率的主要原因，据报道与数百种基因有关。全面了解冠心病相关基因及其对应的相互作用对于推进冠心病的翻译研究至关重要。因此，我们构建了这个知识库，CHD @ ZJU，它记录了从不同资源中收集的与CHD相关的信息（基因，途径，药物和参考），并通过文本挖掘方法，随后进行了手动确认。在当前版本中，CHD @ ZJU包含660种与CHD相关的基因，45种常见途径和1405种药物，并附有> 8000种支持参考文献。冠心病@ZJU中收集的基因中几乎有一半是其他公众可获得的冠心病数据库的新基因。此外，CHD @ ZJU结合了蛋白质之间的相互作用，从多层网络的角度研究了通路内的串扰。 CHD @ ZJU提供的这些功能将使研究人员能够系统地剖析CHD的分子机制，从而促进对CHD相关的多靶点治疗发现的研究。数据库URL：http://tcm.zju.edu.cn/chd/

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《Database》 |2013年第40期|共页
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Jihong Yang; Leihong Wu; Xiang Li; Xiaohui Fan; Yiyu Cheng; Yufeng Liu;
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机译：特征相关分析的基于神经网络的冠心病风险预测
2. Neural Network-Based Coronary Heart Disease Risk Prediction Using Feature Correlation Analysis [J] . Jae Kwon Kim, Sanggil Kang, Eddie Ng Yin Kwee Journal of healthcare engineering. . 2017,第1期

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3. In-depth statistical analysis of the use of a website providing patients’ narratives on lifestyle change when living with chronic back pain or coronary heart disease [J] . Cynthia Richter, Steffi G. Riedel-Heller, Matthias Romppel Journal of the Medical Association of Thailand =: Chotmaihet thangphaet . 2018,第7期

机译：在用慢性背部疼痛或冠心病的生活方式改变患者叙事的网站上使用网站的深入统计分析
4. A Cooperated Data Management Platform for Coronary Heart Disease Early Identification and Risk Warning Research [C] . Peili Yang, Hui Zhao, Xuezhen Yin, IEEE Annual Computer Software and Applications Conference . 2018

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5. Systematic review of genetic risk score in coronary heart disease and other diseases [D] . Sun, Jia 2009

机译：冠心病和其他疾病的遗传风险评分系统评价
6. CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease [O] . Leihong Wu, Xiang Li, Jihong Yang, 2013

机译：CHD @ ZJU：知识库提供基于网络的冠心病研究平台
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8. Control of Lethal Arrhythmias Associated with Coronary Heart Disease. Experimental Studies of Arrhythmias in Relation to Coronary Heart Disease. [R] . abildskov, j. a. 1976

机译：控制与冠心病相关的致死性心律失常。心律失常与冠心病关系的实验研究。

CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease

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