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IQdb: an intelligence quotient score-associated gene resource for human intelligence

机译：IQdb：人类智商的与智商得分相关的基因资源

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Intelligence quotient (IQ) is the most widely used phenotype to characterize human cognitive abilities. Recent advances in studies on human intelligence have identified many new susceptibility genes. However, the genetic mechanisms involved in IQ score and the relationship between IQ score and the risk of mental disorders have won little attention. To address the genetic complexity of IQ score, we have developed IQdb (http://IQdb.cbi.pku.edu.cn), a publicly available database for exploring IQ-associated human genes. In total, we collected 158 experimental verified genes from literature as a core dataset in IQdb. In addition, 46 genomic regions related to IQ score have been curated from literature. Based on the core dataset and 46 confirmed linked genomic regions, more than 6932 potential IQ-related genes are expanded using data of protein–protein interactions. A systematic gene ranking approach was applied to all the collected and expanded genes to represent the relative importance of all the 7090 genes in IQdb. Our further systematic pathway analysis reveals that IQ-associated genes are significantly enriched in multiple signal events, especially related to cognitive systems. Of the 158 genes in the core dataset, 81 are involved in various psychotic and mental disorders. This comprehensive gene resource illustrates the importance of IQdb to our understanding on human intelligence, and highlights the utility of IQdb for elucidating the functions of IQ-associated genes and the cross-talk mechanisms among cognition-related pathways in some mental disorders for community. Database URL: http://IQdb.cbi.pku.edu.cn.
机译：智商（IQ）是表征人类认知能力最广泛使用的表型。人类智力研究的最新进展已经确定了许多新的易感基因。然而，智商评分涉及的遗传机制以及智商评分与精神障碍风险之间的关系很少引起关注。为了解决IQ分数的遗传复杂性，我们开发了IQdb（http://IQdb.cbi.pku.edu.cn），这是一个公开的数据库，用于探索与IQ相关的人类基因。总共，我们从文献中收集了158个经过实验验证的基因，作为IQdb中的核心数据集。另外，从文献中已经鉴定出与智商得分相关的46个基因组区域。基于核心数据集和46个已确认的链接基因组区域，利用蛋白质与蛋白质相互作用的数据扩展了超过6932个与IQ相关的潜在基因。系统的基因排名方法应用于所有收集和扩展的基因，以代表IQdb中所有7090个基因的相对重要性。我们进一步的系统途径分析表明，智商相关基因在多种信号事件中显着丰富，尤其是与认知系统有关。在核心数据集中的158个基因中，有81个涉及各种精神病和精神疾病。这种全面的基因资源说明了IQdb对我们理解人类智力的重要性，并强调了IQdb在阐明社区中某些精神障碍中与IQ相关的基因的功能以及认知相关途径之间的串扰机制的实用性。数据库URL：http：//IQdb.cbi.pku.edu.cn。

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