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PROFESS: a PROtein Function, Evolution, Structure and Sequence database

机译:专业:蛋白功能,进化,结构和序列数据库

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The proliferation of biological databases and the easy access enabled by the Internet is having a beneficial impact on biological sciences and transforming the way research is conducted. There are ~1100 molecular biology databases dispersed throughout the Internet. To assist in the functional, structural and evolutionary analysis of the abundant number of novel proteins continually identified from whole-genome sequencing, we introduce the PROFESS (PROtein Function, Evolution, Structure and Sequence) database. Our database is designed to be versatile and expandable and will not confine analysis to a pre-existing set of data relationships. A fundamental component of this approach is the development of an intuitive query system that incorporates a variety of similarity functions capable of generating data relationships not conceived during the creation of the database. The utility of PROFESS is demonstrated by the analysis of the structural drift of homologous proteins and the identification of potential pancreatic cancer therapeutic targets based on the observation of protein–protein interaction networks. Database URL: http://cse.unl.edu/~profess/
机译:生物数据库的激增和互联网的便捷访问对生物科学产生了有益的影响,并改变了研究方式。互联网上分布着约1100个分子生物学数据库。为了协助从全基因组测序中不断鉴定出的大量新型蛋白质进行功能,结构和进化分析,我们引入了PROFESS(蛋白质功能,进化,结构和序列)数据库。我们的数据库被设计为通用且可扩展的,并且不会将分析范围限制在一组预先存在的数据关系中。该方法的基本组成部分是开发直观的查询系统,该系统结合了多种相似功能,能够生成在数据库创建期间未构想的数据关系。通过对同源蛋白质的结构漂移进行分析,并基于蛋白质与蛋白质相互作用网络的观察,确定潜在的胰腺癌治疗靶标,可以证明PROFESS的实用性。数据库URL:http://cse.unl.edu/~profess/

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