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TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling

机译：TSLP信号通路图：用于分析TSLP介导信号的平台

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Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24
机译：胸腺基质淋巴细胞生成素（TSLP）是一种四螺旋束细胞因子，在调节免疫应答和造血细胞分化中起关键作用。 TSLP通过由白介素7受体α链和独特的TSLP受体（TSLPR）[也称为细胞因子受体样因子2（CRLF2）]组成的异二聚体受体复合物发出信号。 TSLP的细胞靶标包括树突状细胞，B细胞，肥大细胞，调节性T（Treg）细胞以及CD4 +和CD8 + T细胞。 TSLP / TSLPR轴可以激活多种信号转导途径，包括JAK / STAT途径和PI-3激酶途径。 TSLP / TSLPR信号异常与多种人类疾病有关，包括哮喘，特应性皮炎，鼻息肉，炎症性肠病，嗜酸性食管炎，以及最近的急性淋巴细胞性白血病。分类信令事件的TSLP信令路径的集中式资源尚不可用。在这项研究中，我们介绍了TSLP信号通路中反应的文献注释资源。该路径图可通过NetPath（http://www.netpath.org/）公开获得，NetPath是我们小组先前开发的一种开放式访问信号传导路径资源。该图包括涉及TSLP / TSLPR信号通路的236个分子和252个反应。我们期望TSLP信号通路图将提供丰富的资源来研究这种重要细胞因子的生物学特性，并为与TSLP / TSLPR信号失调相关的疾病确定新的治疗靶标。数据库URL：http://www.netpath.org/pathways?path_id=NetPath_24

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