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首页> 外文期刊>Dataset Papers in Science >Comprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets
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Comprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets

机译：使用芯片数据集全面分析正常和肿瘤性人食管鳞状细胞株中MicroRNA和mRNA的表达

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摘要

Despite the undisputed importance of altered microRNA (miRNA) expression in various cancers, there is limited information on the clinicopathologic significance of cancer-related miRNAs in esophageal squamous cell carcinoma (ESCC). Previously, it was reported that the expression of several miRNAs was dysregulated in ESCC. However, the target genes of these miRNAs have not been identified. Furthermore, additional miRNAs in humans have been discovered recently, indicating that revised miRNA and gene expression profiling for ESCC are necessary. Here, we provide datasets from microarray analyses to identify miRNA and mRNA expression comprehensively in Het-1A, a normal human esophageal squamous cell line, and three human ESCC cell lines.
机译：尽管在各种癌症中改变microRNA（miRNA）表达的重要性无可争议，但关于食管鳞状细胞癌（ESCC）中与癌症相关的miRNA的临床病理意义的信息有限。以前，据报道在ESCC中几种miRNA的表达失调。但是，这些miRNA的靶基因尚未确定。此外，最近在人类中发现了其他miRNA，这表明必须对ESCC进行修订的miRNA和基因表达谱分析。在这里，我们提供了来自微阵列分析的数据集，以全面鉴定在Het-1A，正常人食管鳞状细胞系和三种人ESCC细胞系中的miRNA和mRNA表达。

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