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首页> 外文期刊>Dental Hypotheses >Effect of Local and Application of Amitriptyline and Imipramine on Teeth with Irreversible Pulpitis Failed Pulpal Anesthesia: A Randomized, Double-blind, Controlled Trial
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Effect of Local and Application of Amitriptyline and Imipramine on Teeth with Irreversible Pulpitis Failed Pulpal Anesthesia: A Randomized, Double-blind, Controlled Trial

机译：局部和应用阿米替林和丙咪嗪对不可逆性肺炎失败的输卵管麻醉对牙齿的影响：一项随机，双盲，对照试验

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Introduction: To evaluate the analgesic effect of amitriptyline and imipramine after local application on the dentine of “hot teeth” with failed pulpal anesthesia. Materials and Methods: This study was a randomized, double-blind clinical trial that was performed on 33 consenting adult patients who were referred to us and had mandibular molars diagnosed with symptomatic irreversible pulpitis and experienced pain during access cavity preparation after receiving successful inferior alveolar nerve block with lidocaine. Either amitriptyline, imipramine or placebo was administered locally on the exposed dentine of the teeth. Pre and post-application pain levels were evaluated by McGill visual analog scale. Results: Amitriptyline significantly reduced the pain experienced by patients (P = 0.032). Imipramine also reduced the experienced pain but the pain relief was not statistically significant when compared with the placebo. Conclusion: Local administration of amitriptyline on exposed dentine can reduce the pain experienced by patients with a “hot tooth.”
机译：简介：评估局部应用阿米替林和丙咪嗪对牙髓麻醉失败的“热牙”牙本质的镇痛效果。材料和方法：该研究是一项随机，双盲临床试验，对33位同意转诊给我们的成年患者进行，他们接受了成功的下牙槽神经后，下颌磨牙被诊断为有症状的不可逆性牙髓炎，并在进入腔准备过程中出现疼痛利多卡因阻滞。在裸露的牙齿上局部使用阿米替林，丙咪嗪或安慰剂。通过McGill视觉模拟量表评估应用前后的疼痛水平。结果：阿米替林可显着减轻患者的痛苦（P = 0.032）。丙咪嗪也减轻了所经历的疼痛，但与安慰剂相比，疼痛的缓解在统计学上不显着。结论：在暴露的牙本质上局部施用阿米替林可减轻“热牙”患者的痛苦。

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