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首页> 外文期刊>Dental Hypotheses >The periodontal infection may be a contributing factor to the development of gastric cancer
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The periodontal infection may be a contributing factor to the development of gastric cancer

机译：牙周感染可能是导致胃癌发展的因素

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Introduction: Self-reported tooth loss is highly prevalent in patients with gastric cancer, the second most common malignancy worldwide. Periodontal disease is characterized by loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss. The theories have been confirmed that chronic systemic inflammation and increased exposure to carcinogenic nitrosamines can increase the risk of cancer, and periodontal pathogens could induce the chronic inflammation. Poor oral hygiene and periodontal diseases may contribute to greater nitrosamine production. The Hypothesis: We hypothesize that periodontal diseases might be an important risk factor for gastric cancer. Major pathogens of periodontal diseases may play a more direct role through local inflammatory responses and carcinogenic transformations in the development of gastric cancer. Evaluation of the Hypothesis: It is possible that periodontal disease may be a marker of a type of immune function that has implications for tumor growth and progression in stomach. If periodontal bacteria indeed play an important role in the development of gastric cancer, the patients should be treated not only focused on the stomach disease itself but also the periodontal problems.
机译：简介：自我报告的牙齿脱落在胃癌患者中非常普遍，胃癌是全球第二大最常见的恶性肿瘤。牙周疾病的特征在于牙周膜和牙槽骨的缺失，并且是牙齿脱落的主要原因。该理论已被证实，慢性全身性炎症和增加致癌亚硝胺暴露可增加患癌症的风险，而牙周病原体可诱发慢性炎症。不良的口腔卫生和牙周疾病可能有助于增加亚硝胺的产生。假设：我们假设牙周疾病可能是胃癌的重要危险因素。牙周疾病的主要病原体在胃癌的发展中可能通过局部炎症反应和致癌性转化发挥更直接的作用。假说的评估：牙周疾病可能是一种免疫功能的标志物，可能影响胃中肿瘤的生长和进展。如果牙周细菌确实在胃癌的发展中起重要作用，则不仅应针对胃病本身，还应针对牙周疾病进行治疗。

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