• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dental Journal: Majalah Kedokteran Gigi >Hyperplasia of Wistar rat tongue mucosa due to exposure to cigarette side-stream smoke
【24h】

Hyperplasia of Wistar rat tongue mucosa due to exposure to cigarette side-stream smoke

机译：Wistar大鼠舌黏膜增生，暴露于香烟侧流烟

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Hyperplasia, a condition whereby an excessive number of cells are produced due to their uncontrolled division, represents a common symptom of carcinogenesis. Cancer is a physical manifestation of cell malignancy resulting from abnormal proliferation. Globally, oral cancer currently constitutes the sixth largest lethal form of the condition. The most common etiology of oral cancer is tobacco of which cigarettes are the most popular related product . The health risks associated with cigarette smoke not only affect active smokers but also individuals who ingest it passively . Sidestream smoke comes from the lighted end of a burning tobacco product such as a cigarette, pi p e or cigar and contains nicotine and many harmful cancer-causing chemicals. Inhaling sidestream smoke increases the risk of lung and other types of cancer. Purpose: The purpose of this study was to understand how sidestream cigarette smoke initiates precancerous changes, in this case hyperplasia, in the oral mucosa epithelium of Wistar rats . Method s : The subjec ts were divided into three groups, a 4 - week treatment group (P1 ) , an 8-week treatment group (P2 ) , and a control group (K) , each consisting of ten subject s. The subjec ts were exposed to a daily two-cigarette dose of smoke. The experiment used a post-test only control group design. All samples were sacrificed during the fourth and eighth week s . Haematoxylin-eosin staining was performed on the tongue s of the Wistar rats to establish the presence of hyperplasia. Data w as analyzed using a one-way ANOVA test . Results: After the Wistar rats had been exposed to cigarette smoke, an increase d degree of epithelial cell proliferation (hyperplasia) showed a significant difference with a p-value 0.05 during the eighth week. Conclusion: Exposure to cigarette sidestream smoke induces increased epithelial cell proliferation (hyperplasia) in Wistar rat s .
机译：背景：增生是由于细胞不受控制的分裂而产生过多细胞的疾病，是癌变的常见症状。癌症是异常增殖导致的细胞恶性肿瘤的物理表现。在全球范围内，口腔癌目前构成该病的第六大致命形式。口腔癌的最常见病因是烟草，其中香烟是最受欢迎的相关产品。与香烟烟雾有关的健康风险不仅影响主动吸烟者，而且还会影响被动摄入烟的个人。侧流烟气来自燃烧的烟草制品（如香烟，烟斗或雪茄）的点燃末端，其中含有尼古丁和许多有害的致癌化学物质。吸入侧流烟会增加患肺癌和其他类型癌症的风险。目的：本研究的目的是了解侧流香烟烟雾如何引发Wistar大鼠口腔粘膜上皮的癌前变化，在这种情况下为增生。方法：受试者分为三组，一个为期4周的治疗组（P1），一个为期8周的治疗组（P2）和一个对照组（K），每组由10名受试者组成。受试者每天要接受两支香烟的烟熏。实验使用了仅测试后的对照组设计。在第四和第八周将所有样品处死。在Wistar大鼠的舌头上进行苏木精-伊红染色以确定是否存在增生。使用单向方差分析对数据进行分析。结果：Wistar大鼠暴露于香烟烟雾后，第八周上皮细胞增殖（增生）的d程度增加存在显着差异，p值<0.05。结论：暴露于卷烟侧流烟雾可诱导Wistar大鼠上皮细胞增殖（增生）增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号