• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dental Journal: Majalah Kedokteran Gigi >Topical application of 1% ZnSO4 on oral ulcers increases the number of macrophages in normal or diabetic conditions of wistar rats
【24h】

Topical application of 1% ZnSO4 on oral ulcers increases the number of macrophages in normal or diabetic conditions of wistar rats

机译：在wistar大鼠的正常或糖尿病条件下局部施用1％ZnSO4会增加口腔溃疡中的巨噬细胞数量

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Therapy for chronic ulcer in diabetic patient is by modifying local inflammation response using drugs that acts as immunomodulator, neuromodulator and growth factors stimulator. Topical zinc is one of drug that can modifiy local inflammation response, immunostimulation or immunosuppresion. Purpose: This study was to prove about the number of macrophage in oral ulcer between normal and diabetes microscopically and the difference if treated by 1% ZnSO4 gel topically. Method: Ulcer in lower labial mucosa was made in normal and diabetic Wistar rats (induced by STZ), then applied 1% ZnSO4 gel and CMC-Na gel as control. They were decapitated in third and fifth day and specimen was made by processing lower labial mucosa Result: Microscopically, the result showed the number of macrophages in oral ulcer in diabetic condition was significantly higher than normal and the application of 1% ZnSO4 increased the number of macrophages in fifth day. Conclusion: The number of macrophages was higher in diabetic than normal condition, and was proven that topical application of 1% ZnSO4 increased the number macrophages of oral ulcer diabetic and normal condition.
机译：背景：对糖尿病患者的慢性溃疡的治疗是通过使用充当免疫调节剂，神经调节剂和生长因子刺激剂的药物来改变局部炎症反应。局部锌是可以改变局部炎症反应，免疫刺激或免疫抑制的药物之一。目的：本研究旨在通过显微镜证实正常和糖尿病患者口腔溃疡中巨噬细胞的数量，以及局部用1％ZnSO4凝胶治疗的差异。方法：正常和糖尿病Wistar大鼠（STZ诱导）下唇黏膜溃疡形成，然后以1％ZnSO4凝胶和CMC-Na凝胶为对照。结果：在显微镜下，糖尿病患者口腔溃疡中的巨噬细胞数量明显高于正常人，而1％ZnSO4的使用增加了糖尿病患者口腔溃疡的巨噬细胞数量。在第五天的巨噬细胞。结论：糖尿病患者的巨噬细胞数量高于正常情况，并证明局部应用1％ZnSO4可增加糖尿病和正常口腔溃疡的巨噬细胞数量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号