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首页> 外文期刊>Dental Materials Journal >Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials
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Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials

机译：多能间充质前体C2C12细胞在树脂基修复材料上的增殖和分化潜能

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This study investigated the proliferation and differentiation potential of pluripotent mesenchymal cells on three resin-based restoratives using a typical pluripotent mesenchymal precursor cell line, C2C12. C2C12 cells were cultured for 3-21 days on cured specimens of a Bis-GMA/TEGDMA-based composite resin (APX; Clearfil AP-X), a 4-META/MMA-based resin cement (SB; Superbond C&B) or a HEMA-containing resin modified glass-ionomer (LC; Fuji Ionomer Type II LC). To examine the influences on differentiation potential, alkaline phosphatase (ALP) activity of the cells cultured on each material was determined. On APX and SB, cells adhered and proliferated well, and no significant influences on ALP activity were observed. In contrast, poor cell proliferation and significant suppression of ALP activity were observed for cells cultured on LC, similar to those cultured on a zinc oxide EBA cement used as a control material. Bis-GMA/TEGDMA-based composite resin and 4-META/MMA-based resin exhibited better biocompatibility for C2C12 cells than HEMA-containing resin modified glass-ionomer, suggesting a potential advantage of the former two resins to show smaller influences on regeneration of periapical or periodontal tissue.
机译：这项研究使用典型的多能间充质前体细胞系C2C12，研究了多能间充质细胞在三种基于树脂的修复剂上的增殖和分化潜能。将C2C12细胞在Bis-GMA / TEGDMA基复合树脂（APX; Clearfil AP-X），4-META / MMA基树脂胶粘剂（SB; Superbond C＆B）或固化的标本上培养3-21天含HEMA的树脂改性玻璃离聚物（LC; Fuji Ionomer Type II LC）。为了检查对分化潜能的影响，确定了每种材料上培养的细胞的碱性磷酸酶（ALP）活性。在APX和SB上，细胞粘附和增殖良好，没有观察到对ALP活性的显着影响。相反，对于在LC上培养的细胞，类似于在用作对照材料的氧化锌EBA水泥上培养的细胞，观察到不良的细胞增殖和对ALP活性的显着抑制。 Bis-GMA / TEGDMA基复合树脂和4-META / MMA基树脂对C2C12细胞的生物相容性比含HEMA树脂改性的玻璃离聚物更好，这表明前两种树脂的潜在优势显示出对HEMA再生的影响较小。根尖或牙周组织。

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