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首页> 外文期刊>Der Pharmacia Lettre >Formulation and in- vitro permeation studies of Ketoprofen-Ficus reticulatafruit mucilage transdermal patches
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Formulation and in- vitro permeation studies of Ketoprofen-Ficus reticulatafruit mucilage transdermal patches

机译：酮洛芬-无花果粘液透皮贴剂的配制和体外渗透研究

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The main objective of the present study was to develop matrix-moderated transdermal systems of Ketoprofen using various proportions of Ficus reticulata fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro penetration studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Ketoprofen with Ficus reticulata fruit mucilage by the solvent evaporation technique. The interactions between Ketoprofen and Ficus reticulata fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In-vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. Span 80, Glycerin and Propylene glycol in the formulation played a role as permeability enhancers. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus reticulata increased. It was concluded that Ketoprofen can be developed as transdermal patches with Ficus reticulata fruit mucilage.
机译：本研究的主要目的是使用不同比例的网状榕果粘液来开发酮洛芬的基质调节透皮系统。进行了物理评估，例如水分含量，水分吸收，拉伸强度，平坦度和耐折性。在Keshary-Chien扩散池中进行了体外渗透研究。通过溶剂蒸发技术，使用酮洛芬和网状榕果实粘液制备基质型透皮系统。进行了酮洛芬和网状榕果实粘液之间的相互作用。使透皮贴剂经受各种理化参数，即机械性能，渗透研究和皮肤刺激性研究。制备的贴剂具有令人满意的预成型和配方特性。使用Keshary-Chien扩散池跨无毛白化病大鼠皮肤进行体外渗透研究。配方中的Span 80，甘油和丙二醇起着渗透促进剂的作用。贴剂似乎没有潜在的有害皮肤刺激性。实验结果表明，随着网状榕的比例增加，药物从贴剂中的释放以受控的方式延迟。结论是，酮洛芬可以与网状榕果粘液一起制成透皮贴剂。

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