Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione

Rambabu Nunna; Ramach; ran.D; Viral B. Modi; Kirti J.Goswami

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione

【24h】

Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione

机译：2,6-二苯基-3-（4-（3-苯基-[1,2,4]三唑[3,4-b] [1,3,4]噻二唑-6-基的合成，表征和生物学评价）苯基）-2H-1,3,5-恶二嗪-4（3H）-硫酮

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) prepared by treating benzoic acid hydrazide successively with CS2,- KOH and NH2.NH2,give the nitrogen bridge head fused heteocycles (3) on reacting with N-acetyl-p-Amino benzoic acid followed by hydrolysis. It was on facile condensation reaction with various substituted aromatic aldehydes yields Schiff bases/anils/Azomethines (4a-h). These anils on cyclo- addition reaction with benzoyl isothiocyanate afforded 1,3,5-Oxadiazine (5a-h). These compounds were screened for activities against bacterial and fungal strains.

机译：依次用CS2，-KOH和NH2.NH2处理苯甲酰肼制得的4-氨基-5-苯基-4H-1,2,4-三唑-3-硫醇（1），得到氮桥头稠合的杂环（3 ）与N-乙酰基-对氨基苯甲酸反应，然后水解。它与各种取代的芳族醛容易地缩合反应，生成席夫碱/茴香/偶氮甲碱（4a-h）。这些与苯甲酰基异硫氰酸酯进行环加成反应的苯环得到1,3,5-恶二嗪（5a-h）。筛选这些化合物针对细菌和真菌菌株的活性。

著录项

来源
《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第2期|共5页
作者
Rambabu Nunna; Ramach; ran.D; Viral B. Modi; Kirti J.Goswami;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents [J] . Vinod KumarPandey, ZehraTusi, SumerahTusi, International Scholarly Research Notices . 2012,第1期

机译：新型5-[（3-芳烷基酰胺基/亚氨基烷基）苯基] -1,2,4-三唑并[3,4-b] -1,3,4-噻二嗪类抗病毒剂的合成及生物评价
2. Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents [J] . Vinod KumarPandey, ZehraTusi, SumerahTusi, International Scholarly Research Notices . 2012,第6期

机译：新型5-[（3-芳烷基酰胺基/亚氨基烷基）苯基] -1,2,4-三唑并[3,4-b] -1,3,4-噻二嗪类抗病毒剂的合成及生物评价
3. Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones [J] . Nimbalkar Urja D., Tupe Santosh G., Seijas Vazquez Julio A., Molecules . 2016,第5期

机译：超声和分子筛辅助的5-（4-（苄氧基）取代的苯基）-3-（（苯基氨基）甲基）-1,3,4-恶二唑-2（3H）-的合成，分子对接和抗真菌评估硫酮
4. Ultrasound- and Molecular Sieves-Assisted Synthesis Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-134-oxadiazole-2(3H)-thiones [O] . Urja D. Nimbalkar, Santosh G. Tupe, Julio A. Seijas Vazquez, 2016

机译：超声和分子筛辅助的5-（4-（苄氧基）取代的苯基）-3-（（苯基氨基）甲基）-134-恶二唑-2（3H）-的合成分子对接和抗真菌评估硫酮
5. Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3- ((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones [O] . Nimbalkar, Urja D., Tupe, Santosh G., Seijas, Julio A., 2016

机译：超声和分子筛辅助的5-（4-（苄氧基）取代的苯基）-3-（（苯基氨基）甲基）-1,3,4-恶二唑-2（3H）-的合成，分子对接和抗真菌性评估硫酮

Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione

摘要

著录项

相似文献

相关主题

期刊订阅