Boric acid promoted an efficient and practical synthesis of fused pyrimidines in aqueous media

H. M. Meshram; A. Sanjeeva Kumar; G. Santosh Kumar; A. Swetha; B Chennakesava Reddy; P. Ramesh

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Boric acid promoted an efficient and practical synthesis of fused pyrimidines in aqueous media

机译：硼酸促进了水性介质中熔融嘧啶的高效合成

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A very efficient, convenient, mild and practical method is described for the synthesis of fused pyrimidines by three component reaction of β-keto ester, aldehyde and heterocyclic amine in the presence of boric acid in water. The reaction proceeds at rt and yields are high. The method is also amenable for the synthesis of new thiazodihydropyrimidine compounds.

机译：描述了一种非常有效，方便，温和和实用的方法，用于在水中存在硼酸的情况下通过β-酮酸酯，醛和杂环胺的三组分反应合成稠合的嘧啶。反应在室温下进行并且产率很高。该方法也适用于合成新的噻唑二氢嘧啶化合物。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第3期|共5页
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H. M. Meshram; A. Sanjeeva Kumar; G. Santosh Kumar; A. Swetha; B Chennakesava Reddy; P. Ramesh;
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Boric acid promoted an efficient and practical synthesis of fused pyrimidines in aqueous media

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