A new route for the synthesis of (R)- and (S)- 2-((2-oxooxazolidin-5- yl)methyl)isoindoline-1,3-dione: A key chiral building block

G. Ravi Babu; P. Venkateshwarlu; S. Yellam; a Rao; G. Madhusudhan; K. Mukkanti

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >A new route for the synthesis of (R)- and (S)- 2-((2-oxooxazolidin-5- yl)methyl)isoindoline-1,3-dione: A key chiral building block

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A new route for the synthesis of (R)- and (S)- 2-((2-oxooxazolidin-5- yl)methyl)isoindoline-1,3-dione: A key chiral building block

机译：合成（R）-和（S）-2-（（2-氧代恶唑啉丁-5-基）甲基）异吲哚啉-1,3-二酮的新途径：关键的手性构件

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A new and efficient route for the synthesis of (R)- & (S)-2-((2-oxooxazolidin-5-yl)methyl) isoindoline-1,3-dione is described. The enantiopurity of the synthesized two stereoisomers of 2- ((2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione, is established using chiral high performance liquid chromatography (HPLC) i.e. enantiomeric excess (ee) of R & S isomers are 99.5% and 99.6% respectively. This route also involves the synthesis of a key chiral constituent, (R)- & (S)5-(chloromethyl) oxazolidin-2-one.

机译：描述了一种合成（R）-和（S）-2-（（（2-氧代恶唑啉丁-5-基）甲基）异吲哚啉-1,3-二酮的新的有效途径。使用手性高效液相色谱（HPLC）（即R和R的对映体过量（ee））建立了2-（（2-氧代恶唑啉丁-5-基）甲基）异吲哚啉-1,3-二酮的两种合成立体异构体的对映体纯度。 S异构体分别为99.5％和99.6％。该途径还涉及关键手性成分（R）-和（S）5-（氯甲基）恶唑烷-2--2-的合成。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第1期|共6页
作者
G. Ravi Babu; P. Venkateshwarlu; S. Yellam; a Rao; G. Madhusudhan; K. Mukkanti;
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A new route for the synthesis of (R)- and (S)- 2-((2-oxooxazolidin-5- yl)methyl)isoindoline-1,3-dione: A key chiral building block

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