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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Fused pyrimidines: The heterocycle of diverse biological and pharmacological significance
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Fused pyrimidines: The heterocycle of diverse biological and pharmacological significance

机译：融合嘧啶类：具有多种生物学和药理学意义的杂环

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摘要

Fusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds. So, various fused pyrimidines like purines, pteridines, quinazolines, pyridopyrimidines, triazolopyrimidines, pyrazolopyrimidines, pyrimidoazepines, furopyrimidines and pyrrolopyrimidines were studied in the past decade and were found to possess remarkable pharmacological properties. The present review provides a broad view of the biological and medicinal properties expressed by compounds having fused Pyrimidine nucleus.
机译：嘧啶部分与不同杂环支架的融合产生了具有改善的活性的一类新的杂合杂环。在核心结构中含有硫和氮原子的杂环显示出许多药理和生物活性化合物。因此，在过去的十年中研究了各种融合的嘧啶，如嘌呤，蝶啶，喹唑啉，吡啶并嘧啶，三唑并嘧啶，吡唑并嘧啶，嘧啶并氮杂卓，呋喃嘧啶和吡咯并嘧啶，它们具有显着的药理特性。本综述提供了具有嘧啶核稠合的化合物所表达的生物学和医学特性的广阔视野。

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