A facile synthesis of 8-chloro-11-(4-fluorophenyl)-6, 11-dihydro-5H-benzo [5,6] cyclohepta [1, 2-b] pyridin-11-ol

ini R. Pai; esh Vishwasrao; Deepn; an Dubahshi

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >A facile synthesis of 8-chloro-11-(4-fluorophenyl)-6, 11-dihydro-5H-benzo [5,6] cyclohepta [1, 2-b] pyridin-11-ol

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A facile synthesis of 8-chloro-11-(4-fluorophenyl)-6, 11-dihydro-5H-benzo [5,6] cyclohepta [1, 2-b] pyridin-11-ol

机译：轻松合成8-氯-11-（4-氟苯基）-6，11-二氢-5H-苯并[5,6]环庚[1，2-b]吡啶-11-醇

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This study aimed at evaluating the Sedative activity of structurally diverse derivatives of lead compound 8-chloro- 11-(4-fluorophenyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b] pyridin-11-ol; synthesized via straightforward and efficient synthetic process. The structures of the compounds were characterized by spectral data (IR and 1HNMR). The work was extended to study the potential role of the novel derivatives as anti-Parkinson agents.

机译：这项研究旨在评估铅化合物8-氯-11-（4-氟苯基）-6,11-二氢-5H-苯并[5,6]环庚[1,2-b]吡啶的结构多样的衍生物的镇静活性-11-ol;通过简单有效的合成过程合成。化合物的结构通过光谱数据（IR和1HNMR）表征。这项工作已扩展到研究新型衍生物作为抗帕金森剂的潜在作用。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第6期|共7页
作者
ini R. Pai; esh Vishwasrao; Deepn; an Dubahshi;
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机译：法呢基蛋白转移酶的抑制剂。 1-（8-氯-6,11-二氢-5H-苯并（5,6）-环庚（1,2-b）吡啶基-11-yl）的4-氨基，4-氨基甲酰基和4-甲酰胺基衍生物哌嗪和1-（3-溴-8-氯-6,11-二氢-5H-苯并（5,6）环庚（1,2-b）p
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8. Synthesis and Characterization of Stereoisomers of 5,6-Dihydro-5,6-Dihydroxythymidine [R] . Vaishnav, Y., Holwitt, E., Swenberg, C., 1991

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A facile synthesis of 8-chloro-11-(4-fluorophenyl)-6, 11-dihydro-5H-benzo [5,6] cyclohepta [1, 2-b] pyridin-11-ol

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